In vitro lymph node-mimicking 3D model displays long-term T cell-dependent CLL proliferation and survival

Marco Vincent Haselager; Bianca Francisca van Driel; Eduard Perelaer; Dennis de Rooij; Danial Lashgari; Remco Loos; Arnon P. Kater; Perry D. Moerland; Eric Eldering

doi:10.1101/2023.04.03.535388

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In vitro lymph node-mimicking 3D model displays long-term T cell-dependent CLL proliferation and survival

View ORCID ProfileMarco Vincent Haselager, Bianca Francisca van Driel, Eduard Perelaer, Dennis de Rooij, Danial Lashgari, View ORCID ProfileRemco Loos, View ORCID ProfileArnon P. Kater, View ORCID ProfilePerry D. Moerland, View ORCID ProfileEric Eldering

doi: https://doi.org/10.1101/2023.04.03.535388

Marco Vincent Haselager

1Departments of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

4Lymphoma and Myeloma, Center Amsterdam, LYMMCARE, Amsterdam, The Netherlands

5Cancer Center Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

6Cancer Immunology, Amsterdam, The Netherlands

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ORCID record for Marco Vincent Haselager

Bianca Francisca van Driel

2Hematology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

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Eduard Perelaer

1Departments of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

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Dennis de Rooij

2Hematology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

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Danial Lashgari

3Epidemiology and Data Science, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

6Cancer Immunology, Amsterdam, The Netherlands

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Remco Loos

9Center for Innovation and Translational Research Europe, Bristol Myers Squibb, Sevilla, Spain

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Arnon P. Kater

2Hematology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

4Lymphoma and Myeloma, Center Amsterdam, LYMMCARE, Amsterdam, The Netherlands

5Cancer Center Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

6Cancer Immunology, Amsterdam, The Netherlands

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Perry D. Moerland

3Epidemiology and Data Science, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

7Inflammatory Diseases, Amsterdam, The Netherlands

8Amsterdam Public Health, Methodology Amsterdam, The Netherlands

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Eric Eldering

1Departments of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands

4Lymphoma and Myeloma, Center Amsterdam, LYMMCARE, Amsterdam, The Netherlands

5Cancer Center Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

6Cancer Immunology, Amsterdam, The Netherlands

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ORCID record for Eric Eldering
For correspondence: e.eldering@amsterdamumc.nl

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In vitro lymph node-mimicking 3D model displays long-term T cell-dependent CLL proliferation and survival

Marco Vincent Haselager, Bianca Francisca van Driel, Eduard Perelaer, Dennis de Rooij, Danial Lashgari, Remco Loos, Arnon P. Kater, Perry D. Moerland, Eric Eldering

bioRxiv 2023.04.03.535388; doi: https://doi.org/10.1101/2023.04.03.535388

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In vitro lymph node-mimicking 3D model displays long-term T cell-dependent CLL proliferation and survival

Marco Vincent Haselager, Bianca Francisca van Driel, Eduard Perelaer, Dennis de Rooij, Danial Lashgari, Remco Loos, Arnon P. Kater, Perry D. Moerland, Eric Eldering

bioRxiv 2023.04.03.535388; doi: https://doi.org/10.1101/2023.04.03.535388

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