Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Constructing future behaviour in the hippocampal formation through composition and replay

View ORCID ProfileJacob J.W. Bakermans, Joseph Warren, James C.R. Whittington, Timothy E.J. Behrens
doi: https://doi.org/10.1101/2023.04.07.536053
Jacob J.W. Bakermans
1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jacob J.W. Bakermans
  • For correspondence: jacob.bakermans@gmail.com
Joseph Warren
1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK
4Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James C.R. Whittington
1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK
2Department of Applied Physics, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Timothy E.J. Behrens
1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK
3Wellcome Centre for Human Neuroimaging, University College London, London, UK
4Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Hippocampus is critical for memory, imagination, and constructive reasoning. However, recent models have suggested that its neuronal responses can be well explained by state-spaces that model the transitions between experiences. How do we reconcile these two views? Here we show that if state-spaces are constructed compositionally from existing primitives, hippocampal responses can be interpreted as compositional memories, binding these primitives together. Critically, this enables agents to behave optimally in novel environments with no new learning, inferring behaviour directly from the composition. This provides natural interpretations of generalisation and latent learning. Hippocampal replay can build and consolidate these compositional memories, but importantly, due to their compositional nature, it can construct states it has never experienced - effectively building memories of the future. This enables new predictions of optimal replays for novel environments, or after structural changes. Together, these findings provide a framework for reasoning about several seemingly disparate functions of hippocampus.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted April 07, 2023.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Constructing future behaviour in the hippocampal formation through composition and replay
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Constructing future behaviour in the hippocampal formation through composition and replay
Jacob J.W. Bakermans, Joseph Warren, James C.R. Whittington, Timothy E.J. Behrens
bioRxiv 2023.04.07.536053; doi: https://doi.org/10.1101/2023.04.07.536053
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Constructing future behaviour in the hippocampal formation through composition and replay
Jacob J.W. Bakermans, Joseph Warren, James C.R. Whittington, Timothy E.J. Behrens
bioRxiv 2023.04.07.536053; doi: https://doi.org/10.1101/2023.04.07.536053

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4654)
  • Biochemistry (10299)
  • Bioengineering (7614)
  • Bioinformatics (26189)
  • Biophysics (13446)
  • Cancer Biology (10620)
  • Cell Biology (15333)
  • Clinical Trials (138)
  • Developmental Biology (8452)
  • Ecology (12754)
  • Epidemiology (2067)
  • Evolutionary Biology (16763)
  • Genetics (11356)
  • Genomics (15400)
  • Immunology (10548)
  • Microbiology (25041)
  • Molecular Biology (10152)
  • Neuroscience (54096)
  • Paleontology (398)
  • Pathology (1655)
  • Pharmacology and Toxicology (2877)
  • Physiology (4314)
  • Plant Biology (9196)
  • Scientific Communication and Education (1579)
  • Synthetic Biology (2541)
  • Systems Biology (6752)
  • Zoology (1452)