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Multimodal mismatch responses in associative but not primary visual cortex support hierarchical predictive coding in cortical networks

View ORCID ProfileAlice B Van Derveer, View ORCID ProfileJordan M. Ross, View ORCID ProfileJordan P. Hamm
doi: https://doi.org/10.1101/2023.04.12.536573
Alice B Van Derveer
1Neuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303
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Jordan M. Ross
1Neuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303
2Center for Behavioral Neuroscience, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303
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  • For correspondence: jhamm1@gsu.edu
Jordan P. Hamm
1Neuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303
2Center for Behavioral Neuroscience, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303
3Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303
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Abstract

A key function of the mammalian neocortex is to process sensory data in the context of current and past stimuli. Primary sensory cortices, such as V1, respond weakly to stimuli that typical in their context but strongly to novel stimuli, an effect known as “deviance detection”. How deviance detection occurs in associative cortical regions that are downstream of V1 is not well-understood. Here we investigated parietal associative area (PTLp) responses to auditory, visual, and audio-visual mismatches with two-photon calcium imaging and local field potential recordings. We employed basic unisensory auditory and visual oddball paradigms as well as a novel multisensory oddball paradigm, involving typical parings (VaAc or VbAd) presented at p=.88 with rare “deviant” pairings (e.g. VaAd or VbAc) presented at p=.12. We found that PTLp displayed robust deviance detection responses to auditory-visual mismatches, both in individual neurons and in population theta and gamma-band oscillations. In contrast, V1 neurons displayed deviance detection only to visual deviants in a unisensory context, but not to auditory or auditory-visual mismatches. Taken together, these results accord with a predictive processing framework for cortical responses, wherein modality specific prediction errors (i.e. deviance detection responses) are computed in functionally specified cortical areas and feed-forward to update higher brain regions.

Competing Interest Statement

The authors have declared no competing interest.

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Posted April 12, 2023.
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Multimodal mismatch responses in associative but not primary visual cortex support hierarchical predictive coding in cortical networks
Alice B Van Derveer, Jordan M. Ross, Jordan P. Hamm
bioRxiv 2023.04.12.536573; doi: https://doi.org/10.1101/2023.04.12.536573
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Multimodal mismatch responses in associative but not primary visual cortex support hierarchical predictive coding in cortical networks
Alice B Van Derveer, Jordan M. Ross, Jordan P. Hamm
bioRxiv 2023.04.12.536573; doi: https://doi.org/10.1101/2023.04.12.536573

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