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Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Noah J Harris, View ORCID ProfileMeredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, View ORCID ProfileMatthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheekey, View ORCID ProfileScott D Hansen, View ORCID ProfileCalvin K Yip, View ORCID ProfileJohn E Burke
doi: https://doi.org/10.1101/2023.04.12.536585
Noah J Harris
1Department of Biochemistry and Microbiology, University of Victoria,
Meredith L Jenkins
1Department of Biochemistry and Microbiology, University of Victoria,
Sung-Eun Nam
2Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver,
Manoj K Rathinaswamy
1Department of Biochemistry and Microbiology, University of Victoria,
Matthew AH Parson
1Department of Biochemistry and Microbiology, University of Victoria,
Harish Ranga-Prasad
1Department of Biochemistry and Microbiology, University of Victoria,
Udit Dalwadi
2Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver,
Brandon E Moeller
1Department of Biochemistry and Microbiology, University of Victoria,
Eleanor Sheekey
1Department of Biochemistry and Microbiology, University of Victoria,
Scott D Hansen
3Department of Chemistry and Biochemistry, Institute of Molecular Biology, University of Oregon,
Calvin K Yip
2Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver,
John E Burke
1Department of Biochemistry and Microbiology, University of Victoria,
2Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver,
Article usage
Posted May 23, 2023.
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheekey, Scott D Hansen, Calvin K Yip, John E Burke
bioRxiv 2023.04.12.536585; doi: https://doi.org/10.1101/2023.04.12.536585
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheekey, Scott D Hansen, Calvin K Yip, John E Burke
bioRxiv 2023.04.12.536585; doi: https://doi.org/10.1101/2023.04.12.536585
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