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All-in-one AAV-delivered epigenome-editing platform: proof-of-concept and therapeutic implications for neurodegenerative disorders
View ORCID ProfileBoris Kantor, Bernadette Odonovan, Joseph Rittiner, Nicholas Lindner, Wendy Dong, Austin Zhang, Peter Nicholls, Ornit Chiba-Falek
doi: https://doi.org/10.1101/2023.04.14.536951
Boris Kantor
1Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA
2Viral Vector Core, Duke University School of Medicine, Durham, NC 27710, USA
3Center for Advanced Genomic Technologies, Duke University School of Medicine, Durham, NC 27710, USA
Bernadette Odonovan
4Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA
5Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC 27710, USA
Joseph Rittiner
1Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA
2Viral Vector Core, Duke University School of Medicine, Durham, NC 27710, USA
3Center for Advanced Genomic Technologies, Duke University School of Medicine, Durham, NC 27710, USA
Nicholas Lindner
1Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA
2Viral Vector Core, Duke University School of Medicine, Durham, NC 27710, USA
3Center for Advanced Genomic Technologies, Duke University School of Medicine, Durham, NC 27710, USA
Wendy Dong
1Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA
2Viral Vector Core, Duke University School of Medicine, Durham, NC 27710, USA
3Center for Advanced Genomic Technologies, Duke University School of Medicine, Durham, NC 27710, USA
Austin Zhang
1Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA
2Viral Vector Core, Duke University School of Medicine, Durham, NC 27710, USA
3Center for Advanced Genomic Technologies, Duke University School of Medicine, Durham, NC 27710, USA
Peter Nicholls
4Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA
5Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC 27710, USA
Ornit Chiba-Falek
4Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA
5Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC 27710, USA

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted April 16, 2023.
All-in-one AAV-delivered epigenome-editing platform: proof-of-concept and therapeutic implications for neurodegenerative disorders
Boris Kantor, Bernadette Odonovan, Joseph Rittiner, Nicholas Lindner, Wendy Dong, Austin Zhang, Peter Nicholls, Ornit Chiba-Falek
bioRxiv 2023.04.14.536951; doi: https://doi.org/10.1101/2023.04.14.536951
All-in-one AAV-delivered epigenome-editing platform: proof-of-concept and therapeutic implications for neurodegenerative disorders
Boris Kantor, Bernadette Odonovan, Joseph Rittiner, Nicholas Lindner, Wendy Dong, Austin Zhang, Peter Nicholls, Ornit Chiba-Falek
bioRxiv 2023.04.14.536951; doi: https://doi.org/10.1101/2023.04.14.536951
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