Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk

S. Behera; J. R. Belyeu; X. Chen; L. F. Paulin; N.Q.H. Nguyen; E. Newman; M. Mahmoud; V. K. Menon; Q. Qi; P. Joshi; S. Marcovina; M. Rossi; E. Roller; J. Han; V. Onuchic; C. L. Avery; C.M. Ballantyne; C. J. Rodriguez; R. C. Kaplan; D. M. Muzny; G. A. Metcalf; R. Gibbs; B. Yu; E. Boerwinkle; M. A. Eberle; F. J. Sedlazeck

doi:10.1101/2023.04.24.538128

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Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk

View ORCID ProfileS. Behera, View ORCID ProfileJ. R. Belyeu, View ORCID ProfileX. Chen, View ORCID ProfileL. F. Paulin, N.Q.H. Nguyen, E. Newman, View ORCID ProfileM. Mahmoud, V. K. Menon, Q. Qi, P. Joshi, S. Marcovina, View ORCID ProfileM. Rossi, E. Roller, J. Han, View ORCID ProfileV. Onuchic, C. L. Avery, C.M. Ballantyne, C. J. Rodriguez, View ORCID ProfileR. C. Kaplan, D. M. Muzny, G. A. Metcalf, R. Gibbs, View ORCID ProfileB. Yu, E. Boerwinkle, View ORCID ProfileM. A. Eberle, View ORCID ProfileF. J. Sedlazeck

doi: https://doi.org/10.1101/2023.04.24.538128

S. Behera

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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J. R. Belyeu

2Illumina Inc., San Diego, CA, USA

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For correspondence: fritz.sedlazeck@bcm.edu jbelyeu@illumina.com

X. Chen

2Illumina Inc., San Diego, CA, USA

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L. F. Paulin

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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N.Q.H. Nguyen

3School of Public Health, University of Texas Health Science Center at Houston, TX, USA

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E. Newman

2Illumina Inc., San Diego, CA, USA

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M. Mahmoud

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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V. K. Menon

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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Q. Qi

5Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA

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P. Joshi

6Medpace Reference Laboratories, Cincinnati, OH, USA

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S. Marcovina

7University of Texas Southwestern Medical Center, Dallas, TX, USA

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M. Rossi

2Illumina Inc., San Diego, CA, USA

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E. Roller

2Illumina Inc., San Diego, CA, USA

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J. Han

2Illumina Inc., San Diego, CA, USA

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V. Onuchic

2Illumina Inc., San Diego, CA, USA

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C. L. Avery

9Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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C.M. Ballantyne

4Department of Medicine, Baylor College of Medicine, Houston, TX, USA

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C. J. Rodriguez

5Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA

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R. C. Kaplan

5Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA

8Fred Hutchinson Cancer Center, Public Health Sciences Division, Seattle WA 98109

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D. M. Muzny

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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G. A. Metcalf

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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R. Gibbs

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

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B. Yu

3School of Public Health, University of Texas Health Science Center at Houston, TX, USA

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E. Boerwinkle

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

3School of Public Health, University of Texas Health Science Center at Houston, TX, USA

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M. A. Eberle

2Illumina Inc., San Diego, CA, USA

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F. J. Sedlazeck

1Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

10Department of Computer Science, Rice University, 6100 Main Street, Houston, TX, USA

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For correspondence: fritz.sedlazeck@bcm.edu jbelyeu@illumina.com

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Posted April 27, 2023.

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Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk

S. Behera, J. R. Belyeu, X. Chen, L. F. Paulin, N.Q.H. Nguyen, E. Newman, M. Mahmoud, V. K. Menon, Q. Qi, P. Joshi, S. Marcovina, M. Rossi, E. Roller, J. Han, V. Onuchic, C. L. Avery, C.M. Ballantyne, C. J. Rodriguez, R. C. Kaplan, D. M. Muzny, G. A. Metcalf, R. Gibbs, B. Yu, E. Boerwinkle, M. A. Eberle, F. J. Sedlazeck

bioRxiv 2023.04.24.538128; doi: https://doi.org/10.1101/2023.04.24.538128

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