Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells

Juan Manuel Garcia-Arias, Noelia Pinal, Sara Cristóbal Vargas, View ORCID ProfileCarlos Estella, Ginés Morata
doi: https://doi.org/10.1101/2023.05.08.539867
Juan Manuel Garcia-Arias
1Laboratory of Tumorogenesis and Regeneration. Centro de Biología Molecular CSIC-UAM Madrid Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Noelia Pinal
1Laboratory of Tumorogenesis and Regeneration. Centro de Biología Molecular CSIC-UAM Madrid Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sara Cristóbal Vargas
2Laboratory of Gene expression control, patterning and growth during appendage development. Centro de Biología Molecular CSIC-UAM Madrid Spain
3Cancer Research Center-IBMCC (USAL-CSIC), Salamanca, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carlos Estella
2Laboratory of Gene expression control, patterning and growth during appendage development. Centro de Biología Molecular CSIC-UAM Madrid Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Carlos Estella
Ginés Morata
1Laboratory of Tumorogenesis and Regeneration. Centro de Biología Molecular CSIC-UAM Madrid Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: gmorata@cbm.csic.es
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Summary

Programmed cell death (apoptosis) is a homeostasis program of animal tissues designed to remove cells that are unwanted or are damaged by physiological insults. To assess the functional role of apoptosis we have studied the consequences of subjecting Drosophila epithelial cells defective in apoptosis to stress or genetic perturbations that normally cause massive cell death. We find that many of those cells acquire persistent activity of the JNK pathway, which drives them into senescent status, characterized by arrest of cell division, cell hypertrophy, Senescent Associated ß-gal activity (SA-ß-gal), ROS production, Senescent Associated Secretory Phenotype (SASP) and migratory behaviour. We have identified two classes of senescent cells in the wing disc: 1) those that localize to the appendage part of the disc, express the upd, wg and dpp signalling genes and generate tumour overgrowths, and 2) those located in the thoracic region do not express wg and dpp nor they induce tumour overgrowths. Whether to become tumorigenic or non-tumorigenic depends on the original identity of the cell prior to the transformation. We also find that the p53 gene contributes to senescence by enhancing the activity of JNK.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* cestella{at}cbm.csic.es gmorata{at}cbm.csic.es

  • We have just slightly modify the title of the paper.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted May 21, 2023.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells
Juan Manuel Garcia-Arias, Noelia Pinal, Sara Cristóbal Vargas, Carlos Estella, Ginés Morata
bioRxiv 2023.05.08.539867; doi: https://doi.org/10.1101/2023.05.08.539867
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells
Juan Manuel Garcia-Arias, Noelia Pinal, Sara Cristóbal Vargas, Carlos Estella, Ginés Morata
bioRxiv 2023.05.08.539867; doi: https://doi.org/10.1101/2023.05.08.539867

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Developmental Biology
  • Cancer Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4381)
  • Biochemistry (9581)
  • Bioengineering (7087)
  • Bioinformatics (24847)
  • Biophysics (12598)
  • Cancer Biology (9952)
  • Cell Biology (14348)
  • Clinical Trials (138)
  • Developmental Biology (7945)
  • Ecology (12103)
  • Epidemiology (2067)
  • Evolutionary Biology (15985)
  • Genetics (10921)
  • Genomics (14736)
  • Immunology (9869)
  • Microbiology (23648)
  • Molecular Biology (9478)
  • Neuroscience (50841)
  • Paleontology (369)
  • Pathology (1539)
  • Pharmacology and Toxicology (2681)
  • Physiology (4013)
  • Plant Biology (8655)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2391)
  • Systems Biology (6427)
  • Zoology (1346)