The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells

Darren M. Blackburn; Korin Sahinyan; Aldo Hernández-Corchado; Felicia Lazure; Vincent Richard; Laura Raco; René P. Zahedi; Christoph H. Borchers; Christoph Lepper; Hiroshi Kawabe; Arezu Jahani-Asl; Hamed S. Najafabadi; Vahab D. Soleimani

doi:10.1101/2023.05.10.540205

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The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells

Darren M. Blackburn, Korin Sahinyan, Aldo Hernández-Corchado, Felicia Lazure, Vincent Richard, Laura Raco, René P. Zahedi, Christoph H. Borchers, Christoph Lepper, Hiroshi Kawabe, Arezu Jahani-Asl, View ORCID ProfileHamed S. Najafabadi, Vahab D. Soleimani

doi: https://doi.org/10.1101/2023.05.10.540205

Darren M. Blackburn

1Department of Human Genetics, McGill University, 3640 rue University, Montréal, QC, H3A 0C7, Canada

2Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montréal QC, H3T 1E2, Canada

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Korin Sahinyan

1Department of Human Genetics, McGill University, 3640 rue University, Montréal, QC, H3A 0C7, Canada

2Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montréal QC, H3T 1E2, Canada

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Aldo Hernández-Corchado

1Department of Human Genetics, McGill University, 3640 rue University, Montréal, QC, H3A 0C7, Canada

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Felicia Lazure

1Department of Human Genetics, McGill University, 3640 rue University, Montréal, QC, H3A 0C7, Canada

2Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montréal QC, H3T 1E2, Canada

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Vincent Richard

3Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec H3T 1E2, Canada

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Laura Raco

2Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montréal QC, H3T 1E2, Canada

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René P. Zahedi

3Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec H3T 1E2, Canada

4Manitoba Centre for Proteomics and Systems Biology, Winnipeg, MB R3E 3P4, Canada

5Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 3P4, Canada

6Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada

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Christoph H. Borchers

3Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec H3T 1E2, Canada

7Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC H3T 1E2, Canada

8Division of Experimental Medicine, McGill University, Montréal, QC H4A 3J1, Canada

9Department of Pathology, McGill University, Montréal, QC H3A 2B4, Canada

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Christoph Lepper

10Department of Physiology & Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA

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Hiroshi Kawabe

11Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany

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Arezu Jahani-Asl

12Department of Cellular and Molecular Medicine and University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada

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Hamed S. Najafabadi

1Department of Human Genetics, McGill University, 3640 rue University, Montréal, QC, H3A 0C7, Canada

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ORCID record for Hamed S. Najafabadi

Vahab D. Soleimani

1Department of Human Genetics, McGill University, 3640 rue University, Montréal, QC, H3A 0C7, Canada

2Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montréal QC, H3T 1E2, Canada

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For correspondence: vahab.soleimani@mcgill.ca

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The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells

bioRxiv 2023.05.10.540205; doi: https://doi.org/10.1101/2023.05.10.540205

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The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells

bioRxiv 2023.05.10.540205; doi: https://doi.org/10.1101/2023.05.10.540205

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