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Three-dimensional Shear Wave Elastography Using Acoustic Radiation Force and A 2-D Row-Column Addressing (RCA) Array

View ORCID ProfileZhijie Dong, U-Wai Lok, View ORCID ProfileMatthew R. Lowerison, View ORCID ProfileChengwu Huang, Shigao Chen, View ORCID ProfilePengfei Song
doi: https://doi.org/10.1101/2023.05.18.541365
Zhijie Dong
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL
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U-Wai Lok
3Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN
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Matthew R. Lowerison
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL
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Chengwu Huang
3Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN
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Shigao Chen
3Department of Radiology, Mayo Clinic College of Medicine and Science, Rochester, MN
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Pengfei Song
1Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL
4Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL
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  • For correspondence: songp@illinois.edu
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Abstract

Acoustic radiation force (ARF)-based shear wave elastography (SWE) is a clinically available ultrasound imaging mode that noninvasively and quantitatively measures tissue stiffness. Current implementations of ARF-SWE are largely limited to 2-D imaging, which does not provide robust estimation of heterogeneous tissue mechanical properties. Existing 3-D ARF-SWE solutions that are clinically available are based on wobbler probes, which cannot provide true 3-D shear wave motion detection. Although 3-D ARF-SWE based on 2-D matrix arrays have been previously demonstrated, they do not provide a practical solution because of the need for a high channel-count ultrasound system (e.g., 1024-channel) to provide adequate volume rates and the delicate circuitries (e.g., multiplexers) that are vulnerable to the long-duration “push” pulses. To address these issues, here we propose a new 3-D ARF-SWE method based on the 2-D row-column addressing (RCA) array which has a much lower element count (e.g., 256), provides an ultrafast imaging volume rate (e.g., 2000 Hz), and can withstand the push pulses. In this study, we combined the comb-push shear elastography (CUSE) technique with 2-D RCA for enhanced SWE imaging field-of-view. In vitro phantom studies demonstrated that the proposed method had robust 3-D SWE performance in both homogenous and inclusion phantoms. An in vivo study on a breast cancer patient showed that the proposed method could reconstruct 3-D elasticity maps of the breast lesion, which was validated using a commercial ultrasound scanner. These results demonstrate strong potential for the proposed method to provide a viable and practical solution for clinical 3-D ARF-SWE.

Competing Interest Statement

The authors have declared no competing interest.

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Posted May 22, 2023.
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Three-dimensional Shear Wave Elastography Using Acoustic Radiation Force and A 2-D Row-Column Addressing (RCA) Array
Zhijie Dong, U-Wai Lok, Matthew R. Lowerison, Chengwu Huang, Shigao Chen, Pengfei Song
bioRxiv 2023.05.18.541365; doi: https://doi.org/10.1101/2023.05.18.541365
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Three-dimensional Shear Wave Elastography Using Acoustic Radiation Force and A 2-D Row-Column Addressing (RCA) Array
Zhijie Dong, U-Wai Lok, Matthew R. Lowerison, Chengwu Huang, Shigao Chen, Pengfei Song
bioRxiv 2023.05.18.541365; doi: https://doi.org/10.1101/2023.05.18.541365

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