Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

Pablo Mesa; Alicia Jiménez-Fernández; Ruggero La Rosa; Rocio Espinosa; Helle Krogh Johansen; Søren Molin; Guillermo Montoya

doi:10.1101/2023.06.13.544509

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Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

Pablo Mesa, Alicia Jiménez-Fernández, Ruggero La Rosa, Rocio Espinosa, Helle Krogh Johansen, Søren Molin, Guillermo Montoya

doi: https://doi.org/10.1101/2023.06.13.544509

Pablo Mesa

1Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3- B, Copenhagen, 2200, Denmark

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Alicia Jiménez-Fernández

2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark

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Ruggero La Rosa

2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark

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Rocio Espinosa

2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark

5Section of Microbiology and Fermentation, Faculty of Science, University of Copenhagen, 1165 Copenhagen, Denmark

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Helle Krogh Johansen

3Department of Clinical Microbiology, Rigshospitalet, 2100 Copenhagen, Denmark

4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark

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Søren Molin

2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark

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For correspondence: sm@bio.dtu.dk guillermo.montoya@cpr.ku.dk

Guillermo Montoya

1Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3- B, Copenhagen, 2200, Denmark

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For correspondence: sm@bio.dtu.dk guillermo.montoya@cpr.ku.dk

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Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

Pablo Mesa, Alicia Jiménez-Fernández, Ruggero La Rosa, Rocio Espinosa, Helle Krogh Johansen, Søren Molin, Guillermo Montoya

bioRxiv 2023.06.13.544509; doi: https://doi.org/10.1101/2023.06.13.544509

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Detuning of the Ribosome Conformational Landscape Promotes Antibiotic Resistance and Collateral Sensitivity

Pablo Mesa, Alicia Jiménez-Fernández, Ruggero La Rosa, Rocio Espinosa, Helle Krogh Johansen, Søren Molin, Guillermo Montoya

bioRxiv 2023.06.13.544509; doi: https://doi.org/10.1101/2023.06.13.544509

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