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Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
View ORCID ProfileZhikai Zeng, Karen Tsay, Vishnu Vijayan, View ORCID ProfileMatthew P. Frost, Shikhar Prakash, Athena Quddus, Alexa Albert, Michael Vigers, Madhur Srivastava, View ORCID ProfileAmanda L. Woerman, Songi Han
doi: https://doi.org/10.1101/2023.07.19.549721
Zhikai Zeng
1Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, 93105, CA, USA.
Karen Tsay
2Department of Chemistry, Northwestern University, Evanston, 60208, IL, USA.
Vishnu Vijayan
2Department of Chemistry, Northwestern University, Evanston, 60208, IL, USA.
Matthew P. Frost
3Department of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, 01003, MA, USA.
Shikhar Prakash
4Department of Systems Engineering, Cornell University, Ithaca, 14853, NY, USA.
Athena Quddus
5Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, 93105, CA, USA.
Alexa Albert
6Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, 93105, CA, USA.
Michael Vigers
7Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, 93105, CA, USA.
Madhur Srivastava
8ACERT (National Biomedical Center for Advanced ESR Technology), Department of Chemistry and Chemical Biology, Cornell University, Ithaca, 14853, NY, USA.
Amanda L. Woerman
3Department of Biology and Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, 01003, MA, USA.
9Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, 80521, CO, USA.
Songi Han
2Department of Chemistry, Northwestern University, Evanston, 60208, IL, USA.

Article usage
Posted January 02, 2025.
Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
Zhikai Zeng, Karen Tsay, Vishnu Vijayan, Matthew P. Frost, Shikhar Prakash, Athena Quddus, Alexa Albert, Michael Vigers, Madhur Srivastava, Amanda L. Woerman, Songi Han
bioRxiv 2023.07.19.549721; doi: https://doi.org/10.1101/2023.07.19.549721
Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
Zhikai Zeng, Karen Tsay, Vishnu Vijayan, Matthew P. Frost, Shikhar Prakash, Athena Quddus, Alexa Albert, Michael Vigers, Madhur Srivastava, Amanda L. Woerman, Songi Han
bioRxiv 2023.07.19.549721; doi: https://doi.org/10.1101/2023.07.19.549721
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