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Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus

View ORCID ProfileMarco Bocchio, Artem Vorobyev, View ORCID ProfileSadra Sadeh, Sophie Brustlein, Robin Dard, Susanne Reichinnek, View ORCID ProfileValentina Emiliani, Claudia Clopath, Rosa Cossart
doi: https://doi.org/10.1101/2023.09.18.558335
Marco Bocchio
1Aix Marseille Univ, Inserm, INMED, Turing Center for Living Systems, Marseille, France
2Department of Psychology, Durham University, Durham, UK
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  • ORCID record for Marco Bocchio
Artem Vorobyev
1Aix Marseille Univ, Inserm, INMED, Turing Center for Living Systems, Marseille, France
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Sadra Sadeh
3Wavefront-Engineering Microscopy Group, Photonics Department, Vision Institute, Sorbonne University, INSERM, CNRS, Paris, France
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  • ORCID record for Sadra Sadeh
Sophie Brustlein
1Aix Marseille Univ, Inserm, INMED, Turing Center for Living Systems, Marseille, France
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Robin Dard
1Aix Marseille Univ, Inserm, INMED, Turing Center for Living Systems, Marseille, France
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Susanne Reichinnek
1Aix Marseille Univ, Inserm, INMED, Turing Center for Living Systems, Marseille, France
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Valentina Emiliani
3Wavefront-Engineering Microscopy Group, Photonics Department, Vision Institute, Sorbonne University, INSERM, CNRS, Paris, France
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Claudia Clopath
3Wavefront-Engineering Microscopy Group, Photonics Department, Vision Institute, Sorbonne University, INSERM, CNRS, Paris, France
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Rosa Cossart
1Aix Marseille Univ, Inserm, INMED, Turing Center for Living Systems, Marseille, France
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  • For correspondence: rosa.cossart@inserm.fr
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Abstract

Inhibitory interneurons are a critical component of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While many studies have dissected the function of specific interneuron subtypes, the relationship between interneurons and pyramidal cell synchrony in vivo remains unclear. We use an all-optical approach to simultaneously record hippocampal interneurons and pyramidal cells, and test the network influence of single interneurons. We show that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility without altering endogenous cell assemblies. A network model indicates that cell assemblies and dense but unspecific connectivity between interneurons are necessary ingredients to explain our experimental results. Thus, interneurons may not only operate via division of labor, but also through concerted activity. Our data challenge the idea of a purely decorrelating or segregating function of inhibition.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 18, 2023.
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Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus
Marco Bocchio, Artem Vorobyev, Sadra Sadeh, Sophie Brustlein, Robin Dard, Susanne Reichinnek, Valentina Emiliani, Claudia Clopath, Rosa Cossart
bioRxiv 2023.09.18.558335; doi: https://doi.org/10.1101/2023.09.18.558335
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Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus
Marco Bocchio, Artem Vorobyev, Sadra Sadeh, Sophie Brustlein, Robin Dard, Susanne Reichinnek, Valentina Emiliani, Claudia Clopath, Rosa Cossart
bioRxiv 2023.09.18.558335; doi: https://doi.org/10.1101/2023.09.18.558335

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