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Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensates

Nazanin Farahi, Tamas Lazar, Peter Tompa, Bálint Mészáros, Rita Pancsa
doi: https://doi.org/10.1101/2023.09.20.558425

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doi 
https://doi.org/10.1101/2023.09.20.558425
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  • November 20, 2023.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

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  1. Nazanin Farahi1,2,#,
  2. Tamas Lazar1,2,#,
  3. Peter Tompa1,2,3,
  4. Bálint Mészáros4,5,* and
  5. Rita Pancsa3,*
  1. 1VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Pleinlaan 2, 1050 Brussels, Belgium
  2. 2Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium
  3. 3Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, 1117 Budapest, Hungary
  4. 4Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany
  5. 5St Jude Children’s Research Hospital, 262 Danny Thomas Place, 38105 Memphis, TN, USA
  1. ↵*Correspondence may be addressed to: Rita Pancsa (pancsa.rita{at}ttk.hu) or Bálint Mészáros (balint.meszaros{at}stjude.org)

  1. ↵# Co-first authors

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Posted November 20, 2023.
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Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensates
Nazanin Farahi, Tamas Lazar, Peter Tompa, Bálint Mészáros, Rita Pancsa
bioRxiv 2023.09.20.558425; doi: https://doi.org/10.1101/2023.09.20.558425
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