A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

Robert J. Huang; Ignacio A. Wichmann; Andrew Su; Anuja Sathe; Miranda V. Shum; Susan M. Grimes; Rithika Meka; Alison Almeda; Xiangqi Bai; Jeanne Shen; Quan Nguyen; Manuel R. Amieva; Joo Ha Hwang; Hanlee P. Ji

doi:10.1101/2023.09.20.558462

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A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

View ORCID ProfileRobert J. Huang, Ignacio A. Wichmann, Andrew Su, Anuja Sathe, Miranda V. Shum, View ORCID ProfileSusan M. Grimes, Rithika Meka, Alison Almeda, Xiangqi Bai, Jeanne Shen, Quan Nguyen, Manuel R. Amieva, Joo Ha Hwang, Hanlee P. Ji

doi: https://doi.org/10.1101/2023.09.20.558462

Robert J. Huang

1Division of Gastroenterology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Ignacio A. Wichmann

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

3Division of Obstetrics and Gynecology, Department of Obstetrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, 8331150, Chile

4Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Santiago, 8331150, Chile

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Andrew Su

5Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia

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Anuja Sathe

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Miranda V. Shum

1Division of Gastroenterology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Susan M. Grimes

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Rithika Meka

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Alison Almeda

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Xiangqi Bai

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Jeanne Shen

6Department of Pathology, Stanford School of Medicine, Stanford, CA, 94305, USA

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Quan Nguyen

5Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia

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Manuel R. Amieva

7Department of Microbiology and Immunology, Stanford University, Stanford, CA, 94305, USA

8Department of Pediatrics, Stanford University, Stanford, CA, 94305, USA

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Joo Ha Hwang

1Division of Gastroenterology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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Hanlee P. Ji

2Division of Oncology, Department of Medicine, Stanford School of Medicine, Stanford, CA, 94305, USA

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For correspondence: [email protected] [email protected]

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Posted September 22, 2023.

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A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

Robert J. Huang, Ignacio A. Wichmann, Andrew Su, Anuja Sathe, Miranda V. Shum, Susan M. Grimes, Rithika Meka, Alison Almeda, Xiangqi Bai, Jeanne Shen, Quan Nguyen, Manuel R. Amieva, Joo Ha Hwang, Hanlee P. Ji

bioRxiv 2023.09.20.558462; doi: https://doi.org/10.1101/2023.09.20.558462

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