A primordial TFEB-TGFβ signaling axis systemically regulates diapause and stem cell longevity

Tim J. Nonninger; Jennifer Mak; Birgit Gerisch; Valentina Ramponi; Kazuto Kawamura; Klara Schilling; Christian Latza; Jonathan Kölschbach; Roberto Ripa; Manuel Serrano; Adam Antebi

doi:10.1101/2023.10.06.561181

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A primordial TFEB-TGFβ signaling axis systemically regulates diapause and stem cell longevity

Tim J. Nonninger, Jennifer Mak, Birgit Gerisch, Valentina Ramponi, Kazuto Kawamura, Klara Schilling, Christian Latza, Jonathan Kölschbach, Roberto Ripa, Manuel Serrano, View ORCID ProfileAdam Antebi

doi: https://doi.org/10.1101/2023.10.06.561181

Tim J. Nonninger

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Jennifer Mak

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Birgit Gerisch

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Valentina Ramponi

3Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, Barcelona 08028, Spain

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Kazuto Kawamura

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Klara Schilling

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Christian Latza

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Jonathan Kölschbach

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Roberto Ripa

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

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Manuel Serrano

3Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, Barcelona 08028, Spain

4Altos Labs, Cambridge Institute of Science, Granta Park, Cambridge CB21 6GP, UK

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Adam Antebi

1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 50931, Cologne, Germany

2Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674, Cologne, Germany

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ORCID record for Adam Antebi
For correspondence: aantebi@age.mpg.de

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Posted October 06, 2023.

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A primordial TFEB-TGFβ signaling axis systemically regulates diapause and stem cell longevity

Tim J. Nonninger, Jennifer Mak, Birgit Gerisch, Valentina Ramponi, Kazuto Kawamura, Klara Schilling, Christian Latza, Jonathan Kölschbach, Roberto Ripa, Manuel Serrano, Adam Antebi

bioRxiv 2023.10.06.561181; doi: https://doi.org/10.1101/2023.10.06.561181

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A primordial TFEB-TGFβ signaling axis systemically regulates diapause and stem cell longevity

Tim J. Nonninger, Jennifer Mak, Birgit Gerisch, Valentina Ramponi, Kazuto Kawamura, Klara Schilling, Christian Latza, Jonathan Kölschbach, Roberto Ripa, Manuel Serrano, Adam Antebi

bioRxiv 2023.10.06.561181; doi: https://doi.org/10.1101/2023.10.06.561181

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