From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K2P channels

Berke Türkaydin; Marcus Schewe; Elena Riel; Friederike Schulz; Johann Biedermann; Thomas Baukrowitz; Han Sun

doi:10.1101/2023.10.06.561191

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From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K_2P channels

View ORCID ProfileBerke Türkaydin, View ORCID ProfileMarcus Schewe, Elena Riel, Friederike Schulz, Johann Biedermann, View ORCID ProfileThomas Baukrowitz, View ORCID ProfileHan Sun

doi: https://doi.org/10.1101/2023.10.06.561191

Berke Türkaydin

1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

2Insitute of Chemistry, Technical University of Berlin, Berlin, Germany

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Marcus Schewe

3Institute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany

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For correspondence: m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de HSun@fmp-berlin.de

Elena Riel

3Institute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany

4Department of Anesthesiology, Weill Cornell Medical College, New York, USA

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Friederike Schulz

3Institute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany

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Johann Biedermann

1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

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Thomas Baukrowitz

3Institute of Physiology, Christian-Albrechts University of Kiel, Kiel, Germany

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For correspondence: m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de HSun@fmp-berlin.de

Han Sun

1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany

2Insitute of Chemistry, Technical University of Berlin, Berlin, Germany

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For correspondence: m.schewe@physiologie.uni-kiel.de t.baukrowitz@physiologie.uni-kiel.de HSun@fmp-berlin.de

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Posted October 08, 2023.

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From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K_2P channels

Berke Türkaydin, Marcus Schewe, Elena Riel, Friederike Schulz, Johann Biedermann, Thomas Baukrowitz, Han Sun

bioRxiv 2023.10.06.561191; doi: https://doi.org/10.1101/2023.10.06.561191

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From head to tail - Atomistic mechanism of long-range coupling from the cytosolic sensor domain to the selectivity filter in TREK K_2P channels

Berke Türkaydin, Marcus Schewe, Elena Riel, Friederike Schulz, Johann Biedermann, Thomas Baukrowitz, Han Sun

bioRxiv 2023.10.06.561191; doi: https://doi.org/10.1101/2023.10.06.561191

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