Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds

Ashley R. Julio; Flowreen Shikwana; Cindy Truong; Nikolas R. Burton; Emil Dominguez; Alexandra C. Turmon; Jian Cao; Keriann Backus

doi:10.1101/2023.10.30.564067

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Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds

Ashley R. Julio, Flowreen Shikwana, Cindy Truong, Nikolas R. Burton, Emil Dominguez, Alexandra C. Turmon, Jian Cao, View ORCID ProfileKeriann Backus

doi: https://doi.org/10.1101/2023.10.30.564067

Ashley R. Julio

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

bDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 (USA);

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Flowreen Shikwana

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

bDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 (USA);

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Cindy Truong

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

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Nikolas R. Burton

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

bDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 (USA);

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Emil Dominguez

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

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Alexandra C. Turmon

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

bDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 (USA);

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Jian Cao

bDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 (USA);

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Keriann Backus

aDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 (USA)

bDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 (USA);

cDOE Institute for Genomics and Proteomics, UCLA, Los Angeles, CA 90095 (USA)

dJonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095 (USA)

eEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095 (USA)

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ORCID record for Keriann Backus
For correspondence: [email protected]

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Supplementary Information[supplements/564067_file08.pdf]

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Posted November 16, 2023.

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Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds

Ashley R. Julio, Flowreen Shikwana, Cindy Truong, Nikolas R. Burton, Emil Dominguez, Alexandra C. Turmon, Jian Cao, Keriann Backus

bioRxiv 2023.10.30.564067; doi: https://doi.org/10.1101/2023.10.30.564067

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Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds

Ashley R. Julio, Flowreen Shikwana, Cindy Truong, Nikolas R. Burton, Emil Dominguez, Alexandra C. Turmon, Jian Cao, Keriann Backus

bioRxiv 2023.10.30.564067; doi: https://doi.org/10.1101/2023.10.30.564067

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