Enhancer cooperativity can compensate for loss of activity over large genomic distances

Henry Thomas; Songjie Feng; Marie Huber; Vincent Loubiere; Daria Vanina; Mattia Pitasi; Alexander Stark; Christa Buecker

doi:10.1101/2023.12.06.570399

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Enhancer cooperativity can compensate for loss of activity over large genomic distances

View ORCID ProfileHenry Thomas, View ORCID ProfileSongjie Feng, Marie Huber, View ORCID ProfileVincent Loubiere, Daria Vanina, View ORCID ProfileMattia Pitasi, View ORCID ProfileAlexander Stark, View ORCID ProfileChrista Buecker

doi: https://doi.org/10.1101/2023.12.06.570399

Henry Thomas

1Max Perutz Labs, Vienna Biocenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

2University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

3Vienna Biocenter PhD Program, a Doctoral School of the University of Vienna and the Medical University of Vienna, A-1030 Vienna, Austria

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For correspondence: [email protected] [email protected]

Songjie Feng

1Max Perutz Labs, Vienna Biocenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

2University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

3Vienna Biocenter PhD Program, a Doctoral School of the University of Vienna and the Medical University of Vienna, A-1030 Vienna, Austria

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Marie Huber

1Max Perutz Labs, Vienna Biocenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

2University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

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Vincent Loubiere

4Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria

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Daria Vanina

1Max Perutz Labs, Vienna Biocenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

2University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

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Mattia Pitasi

1Max Perutz Labs, Vienna Biocenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

2University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

3Vienna Biocenter PhD Program, a Doctoral School of the University of Vienna and the Medical University of Vienna, A-1030 Vienna, Austria

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Alexander Stark

4Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria

5Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria

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Christa Buecker

1Max Perutz Labs, Vienna Biocenter Campus (VBC), Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

2University of Vienna, Center for Molecular Biology, Department of Microbiology, Immunobiology and Genetics, Dr.-Bohr-Gasse 9, 1030 Vienna, Austria

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For correspondence: [email protected] [email protected]

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Posted December 07, 2023.

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Enhancer cooperativity can compensate for loss of activity over large genomic distances

Henry Thomas, Songjie Feng, Marie Huber, Vincent Loubiere, Daria Vanina, Mattia Pitasi, Alexander Stark, Christa Buecker

bioRxiv 2023.12.06.570399; doi: https://doi.org/10.1101/2023.12.06.570399

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Enhancer cooperativity can compensate for loss of activity over large genomic distances

Henry Thomas, Songjie Feng, Marie Huber, Vincent Loubiere, Daria Vanina, Mattia Pitasi, Alexander Stark, Christa Buecker

bioRxiv 2023.12.06.570399; doi: https://doi.org/10.1101/2023.12.06.570399

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