ABSTRACT
Geneset enrichment analysis is foundational to the interpretation of high throughput biology. We here present GOAT (https://ftwkoopmans.github.io/goat), a parameter-free permutation-based algorithm for geneset enrichment analysis of preranked genelists. Estimated geneset p-values are well calibrated under the null hypothesis and invariant to geneset size. GOAT consistently identifies more Gene Ontology terms in real-world datasets than current methods and is available as an R package and online tool.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Email: frank.koopmans{at}vu.nl
updated URL; updated Figure 2,S2,S4 + results following GOAT R package updates
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted February 05, 2024.
