Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

Naveen Kumar; Richa Sood; Chhedi Lal Gupta; Sandeep Bhatia; Manoj Kumar; S. Nagarajan; C. Tosh; H.V. Murugkar; Aniket Sanyal

doi:10.1101/2023.12.15.571865

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Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

View ORCID ProfileNaveen Kumar, Richa Sood, Chhedi Lal Gupta, Sandeep Bhatia, Manoj Kumar, S. Nagarajan, C. Tosh, H.V. Murugkar, Aniket Sanyal

doi: https://doi.org/10.1101/2023.12.15.571865

Naveen Kumar

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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For correspondence: [email protected]

Richa Sood

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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Chhedi Lal Gupta

2Department of Computer Science, University College London, Gower street, WC1E 6BT, London, UK

3ICMR- National Institute of Immunohaematology, Mumbai, India

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Sandeep Bhatia

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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Manoj Kumar

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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S. Nagarajan

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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C. Tosh

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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H.V. Murugkar

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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Aniket Sanyal

1ICAR- National Institute of High Security Animal Diseases, Bhopal, India

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Z scores were close to experimentally determined protein structure) and ProQ servers (LG scores > 2.5 and MaxSub scores > 0.3)[supplements/571865_file02.docx]

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Posted December 15, 2023.

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Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

Naveen Kumar, Richa Sood, Chhedi Lal Gupta, Sandeep Bhatia, Manoj Kumar, S. Nagarajan, C. Tosh, H.V. Murugkar, Aniket Sanyal

bioRxiv 2023.12.15.571865; doi: https://doi.org/10.1101/2023.12.15.571865

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Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

Naveen Kumar, Richa Sood, Chhedi Lal Gupta, Sandeep Bhatia, Manoj Kumar, S. Nagarajan, C. Tosh, H.V. Murugkar, Aniket Sanyal

bioRxiv 2023.12.15.571865; doi: https://doi.org/10.1101/2023.12.15.571865

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