Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

Kyung Ku Jang; Defne Ercelen; Jing Yu Carolina Cen Feng; Sakteesh Gurunathan; Chaoting Zhou; Aryeh Korman; Luke Newell; David Hudesman; Drew R. Jones; P’ng Loke; Jordan E. Axelrad; Ken Cadwell

doi:10.1101/2024.03.02.583137

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Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

View ORCID ProfileKyung Ku Jang, Defne Ercelen, Jing Yu Carolina Cen Feng, Sakteesh Gurunathan, Chaoting Zhou, Aryeh Korman, Luke Newell, David Hudesman, Drew R. Jones, P’ng Loke, Jordan E. Axelrad, Ken Cadwell

doi: https://doi.org/10.1101/2024.03.02.583137

Kyung Ku Jang

1Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA

2Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, South Korea

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ORCID record for Kyung Ku Jang
For correspondence: Ken.Cadwell@Pennmedicine.upenn.edu Jordan.Axelrad@nyulangone.org kyungkujang@yuhs.ac

Defne Ercelen

3Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA

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Jing Yu Carolina Cen Feng

3Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA

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Sakteesh Gurunathan

3Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA

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Chaoting Zhou

4Cell and Molecular Biology Graduate Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

5Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

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Aryeh Korman

6Metabolomics Core Resource Laboratory, New York University Grossman School of Medicine, NY 10016, USA

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Luke Newell

3Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA

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David Hudesman

3Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA

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Drew R. Jones

6Metabolomics Core Resource Laboratory, New York University Grossman School of Medicine, NY 10016, USA

7Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, NY 10016, USA

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P’ng Loke

8Type 2 Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, 20892, USA

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Jordan E. Axelrad

3Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA

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For correspondence: Ken.Cadwell@Pennmedicine.upenn.edu Jordan.Axelrad@nyulangone.org kyungkujang@yuhs.ac

Ken Cadwell

5Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

9Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

10Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

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For correspondence: Ken.Cadwell@Pennmedicine.upenn.edu Jordan.Axelrad@nyulangone.org kyungkujang@yuhs.ac

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Posted March 06, 2024.

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Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

Kyung Ku Jang, Defne Ercelen, Jing Yu Carolina Cen Feng, Sakteesh Gurunathan, Chaoting Zhou, Aryeh Korman, Luke Newell, David Hudesman, Drew R. Jones, P’ng Loke, Jordan E. Axelrad, Ken Cadwell

bioRxiv 2024.03.02.583137; doi: https://doi.org/10.1101/2024.03.02.583137

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Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness

Kyung Ku Jang, Defne Ercelen, Jing Yu Carolina Cen Feng, Sakteesh Gurunathan, Chaoting Zhou, Aryeh Korman, Luke Newell, David Hudesman, Drew R. Jones, P’ng Loke, Jordan E. Axelrad, Ken Cadwell

bioRxiv 2024.03.02.583137; doi: https://doi.org/10.1101/2024.03.02.583137

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