Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

Aarti Singh; Manuel Rigon; Marta Gramaça Caldeira; Danilo Faccenda; Dong Xia; Jordi Lopez-Tremoleda; Zahra Falah Hassan Al-Khateeb; Tong Guo; Rosella Abeti; Paola Giunti; Michelangelo Campanella

doi:10.1101/2024.03.18.585507

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Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

Aarti Singh, Manuel Rigon, Marta Gramaça Caldeira, Danilo Faccenda, Dong Xia, Jordi Lopez-Tremoleda, View ORCID ProfileZahra Falah Hassan Al-Khateeb, Tong Guo, Rosella Abeti, Paola Giunti, Michelangelo Campanella

doi: https://doi.org/10.1101/2024.03.18.585507

Aarti Singh

1Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, NW1 0TU, London, United Kingdom;

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Manuel Rigon

4Department of Biology, University of Rome TorVergata, 00133 Rome, Italy

7William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ United Kingdom

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Marta Gramaça Caldeira

1Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, NW1 0TU, London, United Kingdom;

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Danilo Faccenda

6Department of Clinical, Pharmaceutical and Biological Science, University of Hertfordshire, Hatfield, AL10 9AB, United Kingdom

7William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ United Kingdom

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Dong Xia

1Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, NW1 0TU, London, United Kingdom;

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Jordi Lopez-Tremoleda

5Barts Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, 4 Newark Street, London, E1 2AT, United Kingdom

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Zahra Falah Hassan Al-Khateeb

5Barts Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, 4 Newark Street, London, E1 2AT, United Kingdom

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ORCID record for Zahra Falah Hassan Al-Khateeb

Tong Guo

7William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ United Kingdom

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Rosella Abeti

3Ataxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom

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Paola Giunti

3Ataxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom

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Michelangelo Campanella

2University College London Consortium for Mitochondrial Research, WC1 0TU Gower Street, London, United Kingdom,

7William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ United Kingdom

8Institute Gustave Roussy, 94805, France

9Department of Biomedical Science, University of Padua, 35131, Italy

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For correspondence: [email protected]

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Posted March 25, 2024.

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Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

Aarti Singh, Manuel Rigon, Marta Gramaça Caldeira, Danilo Faccenda, Dong Xia, Jordi Lopez-Tremoleda, Zahra Falah Hassan Al-Khateeb, Tong Guo, Rosella Abeti, Paola Giunti, Michelangelo Campanella

bioRxiv 2024.03.18.585507; doi: https://doi.org/10.1101/2024.03.18.585507

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Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

Aarti Singh, Manuel Rigon, Marta Gramaça Caldeira, Danilo Faccenda, Dong Xia, Jordi Lopez-Tremoleda, Zahra Falah Hassan Al-Khateeb, Tong Guo, Rosella Abeti, Paola Giunti, Michelangelo Campanella

bioRxiv 2024.03.18.585507; doi: https://doi.org/10.1101/2024.03.18.585507

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