Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

Desirée Böck; Maria Wilhelm; Jonas Mumenthaler; Daniel Fabio Carpanese; Peter I. Kulcsár; Simon d‘Aquin; Alessio Cremonesi; Anahita Rassi; Johannes Häberle; Tommaso Patriarchi; Gerald Schwank

doi:10.1101/2024.03.22.586274

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Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

View ORCID ProfileDesirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Peter I. Kulcsár, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, View ORCID ProfileTommaso Patriarchi, View ORCID ProfileGerald Schwank

doi: https://doi.org/10.1101/2024.03.22.586274

Desirée Böck

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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ORCID record for Desirée Böck
For correspondence: patriarchi@pharma.uzh.ch schwank@pharma.uzh.ch desiree.boeck@uzh.ch

Maria Wilhelm

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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Jonas Mumenthaler

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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Daniel Fabio Carpanese

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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Peter I. Kulcsár

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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Simon d‘Aquin

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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Alessio Cremonesi

2Division of Clinical Chemistry and Biochemistry, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland

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Anahita Rassi

2Division of Clinical Chemistry and Biochemistry, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland

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Johannes Häberle

3Division of Metabolism and Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland

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Tommaso Patriarchi

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

4Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

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For correspondence: patriarchi@pharma.uzh.ch schwank@pharma.uzh.ch desiree.boeck@uzh.ch

Gerald Schwank

1Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

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For correspondence: patriarchi@pharma.uzh.ch schwank@pharma.uzh.ch desiree.boeck@uzh.ch

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Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

Desirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Peter I. Kulcsár, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwank

bioRxiv 2024.03.22.586274; doi: https://doi.org/10.1101/2024.03.22.586274

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Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

Desirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Peter I. Kulcsár, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwank

bioRxiv 2024.03.22.586274; doi: https://doi.org/10.1101/2024.03.22.586274

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