Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring

Ana Isabel Fernandes; Alexandre Jorge Pinto; Diogo Silvério; Ulrike Zedler; Carolina Ferreira; Iola F. Duarte; Ricardo Silvestre; Anca Dorhoi; Margarida Saraiva

doi:10.1101/2024.06.10.598180

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Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring

Ana Isabel Fernandes, Alexandre Jorge Pinto, Diogo Silvério, Ulrike Zedler, Carolina Ferreira, Iola F. Duarte, Ricardo Silvestre, Anca Dorhoi, View ORCID ProfileMargarida Saraiva

doi: https://doi.org/10.1101/2024.06.10.598180

Ana Isabel Fernandes

1Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal

2Doctoral Program in Molecular and Cell Biology, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

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Alexandre Jorge Pinto

1Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal

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Diogo Silvério

1Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal

2Doctoral Program in Molecular and Cell Biology, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal

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Ulrike Zedler

3Institute of Immunology, Friedrich-Loeffler-Institut (FLI), Greifswald-Insel Riems, Germany

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Carolina Ferreira

4Life and Health Sciences, Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

5ICVS/3B’s-PT Government Associate Laboratory, Braga, Portugal

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Iola F. Duarte

6CICECO – Aveiro Institute of Material, Department of Chemistry, University of Aveiro, Aveiro, Portugal

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Ricardo Silvestre

4Life and Health Sciences, Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

5ICVS/3B’s-PT Government Associate Laboratory, Braga, Portugal

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Anca Dorhoi

3Institute of Immunology, Friedrich-Loeffler-Institut (FLI), Greifswald-Insel Riems, Germany

7Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany

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Margarida Saraiva

1Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal

8IBMC – Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal

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ORCID record for Margarida Saraiva
For correspondence: margarida.saraiva@i3s.up.pt

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Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring

Ana Isabel Fernandes, Alexandre Jorge Pinto, Diogo Silvério, Ulrike Zedler, Carolina Ferreira, Iola F. Duarte, Ricardo Silvestre, Anca Dorhoi, Margarida Saraiva

bioRxiv 2024.06.10.598180; doi: https://doi.org/10.1101/2024.06.10.598180

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Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring

Ana Isabel Fernandes, Alexandre Jorge Pinto, Diogo Silvério, Ulrike Zedler, Carolina Ferreira, Iola F. Duarte, Ricardo Silvestre, Anca Dorhoi, Margarida Saraiva

bioRxiv 2024.06.10.598180; doi: https://doi.org/10.1101/2024.06.10.598180

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