LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-derived iPSC Differentiation Support Cell type and Lineage-specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency

Michael V. Zaragoza; Thuy-Anh Bui; Halida P. Widyastuti; Mehrsa Mehrabi; Zixuan Cang; Yutong Sha; Anna Grosberg; Qing Nie

doi:10.1101/2024.06.12.598335

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LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-derived iPSC Differentiation Support Cell type and Lineage-specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency

Michael V. Zaragoza, Thuy-Anh Bui, Halida P. Widyastuti, Mehrsa Mehrabi, View ORCID ProfileZixuan Cang, Yutong Sha, Anna Grosberg, Qing Nie

doi: https://doi.org/10.1101/2024.06.12.598335

Michael V. Zaragoza

1UCI Cardiogenomics Program, Pediatrics and Biological Chemistry, UC Irvine School of Medicine;

2Sue & Bill Gross Stem Cell Research Center, UCI;

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For correspondence: mzaragoz@hs.uci.edu

Thuy-Anh Bui

1UCI Cardiogenomics Program, Pediatrics and Biological Chemistry, UC Irvine School of Medicine;

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Halida P. Widyastuti

1UCI Cardiogenomics Program, Pediatrics and Biological Chemistry, UC Irvine School of Medicine;

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Mehrsa Mehrabi

3Biomedical Engineering and Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, UCI;

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Zixuan Cang

4Mathematics and NSF-Simons Center for Multiscale Cell Fate Research, UCI

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ORCID record for Zixuan Cang

Yutong Sha

4Mathematics and NSF-Simons Center for Multiscale Cell Fate Research, UCI

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Anna Grosberg

2Sue & Bill Gross Stem Cell Research Center, UCI;

3Biomedical Engineering and Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, UCI;

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Qing Nie

4Mathematics and NSF-Simons Center for Multiscale Cell Fate Research, UCI

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Posted June 14, 2024.

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LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-derived iPSC Differentiation Support Cell type and Lineage-specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency