Genetic ablation of the DNA demethylation pathway in retinal progenitor cells impairs photoreceptor development and function, leading to retinal dystrophy

Galina Dvoriantchikova; Chloe Moulin; Michelle Fleishaker; Vania Almeida; Daniel Pelaez; Byron L. Lam; Dmitry Ivanov

doi:10.1101/2024.06.19.599771

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Genetic ablation of the DNA demethylation pathway in retinal progenitor cells impairs photoreceptor development and function, leading to retinal dystrophy

Galina Dvoriantchikova, Chloe Moulin, Michelle Fleishaker, Vania Almeida, Daniel Pelaez, Byron L. Lam, Dmitry Ivanov

doi: https://doi.org/10.1101/2024.06.19.599771

Galina Dvoriantchikova

1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

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Chloe Moulin

1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

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Michelle Fleishaker

1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

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Vania Almeida

2The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, FL, 33136, USA

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Daniel Pelaez

1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

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Byron L. Lam

1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

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Dmitry Ivanov

1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

3Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

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For correspondence: divanov@med.miami.edu

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Genetic ablation of the DNA demethylation pathway in retinal progenitor cells impairs photoreceptor development and function, leading to retinal dystrophy

Galina Dvoriantchikova, Chloe Moulin, Michelle Fleishaker, Vania Almeida, Daniel Pelaez, Byron L. Lam, Dmitry Ivanov

bioRxiv 2024.06.19.599771; doi: https://doi.org/10.1101/2024.06.19.599771

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Genetic ablation of the DNA demethylation pathway in retinal progenitor cells impairs photoreceptor development and function, leading to retinal dystrophy

Galina Dvoriantchikova, Chloe Moulin, Michelle Fleishaker, Vania Almeida, Daniel Pelaez, Byron L. Lam, Dmitry Ivanov

bioRxiv 2024.06.19.599771; doi: https://doi.org/10.1101/2024.06.19.599771

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