Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich; Kai Gallant; Sarah Recknagel; Stavroula Petroulia; Siska Führer; Karel Bezstarosti; Rachel O’Dea; Jeroen Demmers; Malte Gersch

doi:10.1101/2024.07.07.602376

New Results

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

View ORCID ProfileKim Wendrich, View ORCID ProfileKai Gallant, Sarah Recknagel, Stavroula Petroulia, Siska Führer, Karel Bezstarosti, View ORCID ProfileRachel O’Dea, View ORCID ProfileJeroen Demmers, View ORCID ProfileMalte Gersch

doi: https://doi.org/10.1101/2024.07.07.602376

Kim Wendrich

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kim Wendrich

Kai Gallant

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kai Gallant

Sarah Recknagel

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stavroula Petroulia

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Siska Führer

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Karel Bezstarosti

3Erasmus University Medical Center, Proteomics Center, Rotterdam, the Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rachel O’Dea

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

4Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rachel O’Dea

Jeroen Demmers

3Erasmus University Medical Center, Proteomics Center, Rotterdam, the Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jeroen Demmers

Malte Gersch

1Max Planck Institute of Molecular Physiology, Chemical Genomics Centre, Dortmund, Germany

2TU Dortmund University, Department of Chemistry and Chemical Biology, Dortmund, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Malte Gersch
For correspondence: [email protected]

Abstract
Full Text
Info/History
Metrics
Preview PDF

Article usage

Article usage: July 2024 to March 2025

	Abstract	Full	Pdf
Jul 2024	1155	66	319
Aug 2024	116	45	53
Sep 2024	131	38	57
Oct 2024	189	79	93
Nov 2024	141	59	66
Dec 2024	75	38	24
Jan 2025	36	21	15
Feb 2025	20	9	16
Mar 2025	4	9	2

View the discussion thread.

PreviousNext

Posted July 07, 2024.

Download PDF

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich, Kai Gallant, Sarah Recknagel, Stavroula Petroulia, Siska Führer, Karel Bezstarosti, Rachel O’Dea, Jeroen Demmers, Malte Gersch

bioRxiv 2024.07.07.602376; doi: https://doi.org/10.1101/2024.07.07.602376

Share This Article:

Citation Tools

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich, Kai Gallant, Sarah Recknagel, Stavroula Petroulia, Siska Führer, Karel Bezstarosti, Rachel O’Dea, Jeroen Demmers, Malte Gersch

bioRxiv 2024.07.07.602376; doi: https://doi.org/10.1101/2024.07.07.602376

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Biochemistry

Subject Areas

All Articles

Animal Behavior and Cognition (6190)
Biochemistry (14121)
Bioengineering (10790)
Bioinformatics (34225)
Biophysics (17608)
Cancer Biology (14700)
Cell Biology (20721)
Clinical Trials (138)
Developmental Biology (11155)
Ecology (16470)
Epidemiology (2067)
Evolutionary Biology (20773)
Genetics (13649)
Genomics (19056)
Immunology (14196)
Microbiology (33066)
Molecular Biology (13790)
Neuroscience (72195)
Paleontology (539)
Pathology (2274)
Pharmacology and Toxicology (3852)
Physiology (6089)
Plant Biology (12362)
Scientific Communication and Education (1835)
Synthetic Biology (3447)
Systems Biology (8353)
Zoology (1905)