Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

Jiantao Wang; Robert Strauss; Jiri Bartek; Sean G Rudd

doi:10.1101/2024.07.19.604261

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Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

View ORCID ProfileJiantao Wang, View ORCID ProfileRobert Strauss, View ORCID ProfileJiri Bartek, View ORCID ProfileSean G Rudd

doi: https://doi.org/10.1101/2024.07.19.604261

Jiantao Wang

1Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

2Department of Radiation Oncology, West China Hospital, Sichuan University, Chengdu, China

3Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China

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Robert Strauss

4Danish Cancer Institute, Genome Integrity Group, Copenhagen, Denmark

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Jiri Bartek

4Danish Cancer Institute, Genome Integrity Group, Copenhagen, Denmark

5Science for Life Laboratory (SciLifeLab), Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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Sean G Rudd

1Science for Life Laboratory (SciLifeLab), Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

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For correspondence: sean.rudd@scilifelab.se

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Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

Jiantao Wang, Robert Strauss, Jiri Bartek, Sean G Rudd

bioRxiv 2024.07.19.604261; doi: https://doi.org/10.1101/2024.07.19.604261

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Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

Jiantao Wang, Robert Strauss, Jiri Bartek, Sean G Rudd

bioRxiv 2024.07.19.604261; doi: https://doi.org/10.1101/2024.07.19.604261

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