Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease

Liam Horan-Portelance; Michiyo Iba; Dominic J. Acri; J. Raphael Gibbs; Eliezer Masliah; Mark R. Cookson

doi:10.1101/2024.07.31.606032

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Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease

View ORCID ProfileLiam Horan-Portelance, View ORCID ProfileMichiyo Iba, View ORCID ProfileDominic J. Acri, View ORCID ProfileJ. Raphael Gibbs, View ORCID ProfileEliezer Masliah, View ORCID ProfileMark R. Cookson

doi: https://doi.org/10.1101/2024.07.31.606032

Liam Horan-Portelance

1Molecular Neuropathology Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

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ORCID record for Liam Horan-Portelance

Michiyo Iba

1Molecular Neuropathology Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

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ORCID record for Michiyo Iba

Dominic J. Acri

2Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

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J. Raphael Gibbs

3Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

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ORCID record for J. Raphael Gibbs

Eliezer Masliah

1Molecular Neuropathology Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

4Division of Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

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Mark R. Cookson

2Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA

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ORCID record for Mark R. Cookson
For correspondence: cookson@mail.nih.gov

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Posted August 01, 2024.

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Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease

Liam Horan-Portelance, Michiyo Iba, Dominic J. Acri, J. Raphael Gibbs, Eliezer Masliah, Mark R. Cookson

bioRxiv 2024.07.31.606032; doi: https://doi.org/10.1101/2024.07.31.606032

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Single-cell spatial transcriptomics reveals molecular patterns of selective neuronal vulnerability to α-synuclein pathology in a transgenic mouse model of Lewy body disease

Liam Horan-Portelance, Michiyo Iba, Dominic J. Acri, J. Raphael Gibbs, Eliezer Masliah, Mark R. Cookson

bioRxiv 2024.07.31.606032; doi: https://doi.org/10.1101/2024.07.31.606032

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