Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

Chen-Yi Liao; Jasmijn HM Hundscheid; Justin Crawford; Peter ten Dijke; Beatrice Coorneaert; Erik HJ Danen

doi:10.1101/2024.08.26.609699

New Results

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

View ORCID ProfileChen-Yi Liao, Jasmijn HM Hundscheid, Justin Crawford, Peter ten Dijke, Beatrice Coorneaert, Erik HJ Danen

doi: https://doi.org/10.1101/2024.08.26.609699

Chen-Yi Liao

1Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chen-Yi Liao

Jasmijn HM Hundscheid

1Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Justin Crawford

2Galapagos NV, Mechelen, Belgium

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter ten Dijke

3Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Beatrice Coorneaert

2Galapagos NV, Mechelen, Belgium

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Erik HJ Danen

1Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: [email protected]

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: August 2024 to March 2025

	Abstract	Full	Pdf
Aug 2024	361	8	80
Sep 2024	97	16	111
Oct 2024	38	11	13
Nov 2024	45	9	26
Dec 2024	24	15	20
Jan 2025	57	18	33
Feb 2025	11	7	24
Mar 2025	10	8	17

View the discussion thread.

PreviousNext

Posted August 27, 2024.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

Chen-Yi Liao, Jasmijn HM Hundscheid, Justin Crawford, Peter ten Dijke, Beatrice Coorneaert, Erik HJ Danen

bioRxiv 2024.08.26.609699; doi: https://doi.org/10.1101/2024.08.26.609699

Share This Article:

Citation Tools

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity

Chen-Yi Liao, Jasmijn HM Hundscheid, Justin Crawford, Peter ten Dijke, Beatrice Coorneaert, Erik HJ Danen

bioRxiv 2024.08.26.609699; doi: https://doi.org/10.1101/2024.08.26.609699

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Cell Biology

Subject Areas

All Articles

Animal Behavior and Cognition (6229)
Biochemistry
Biochemistry (14223)
Bioengineering (10855)
Bioinformatics (34377)
Biophysics (17695)
Cancer Biology (14788)
Cell Biology (20855)
Clinical Trials (138)
Developmental Biology (11217)
Ecology (16548)
Epidemiology (2067)
Evolutionary Biology (20852)
Genetics (13705)
Genomics (19135)
Immunology (14283)
Microbiology (33277)
Molecular Biology (13877)
Neuroscience (72595)
Paleontology (544)
Pathology (2283)
Pharmacology and Toxicology (3869)
Physiology (6123)
Plant Biology (12434)
Scientific Communication and Education (1840)
Synthetic Biology (3469)
Systems Biology (8388)
Zoology (1919)