Abstract
Retinal bipolar cells (BCs) convey visual signals from photoreceptors to more than 50 types of rabbit retinal ganglion cells (Famiglietti, 2020). More than 40 years ago, 10-11 types of bipolar cell were recognized in rabbit and cat retinas (Famiglietti, 1981). Twenty years later 10 were identified in mouse, rat, and monkey, while recent molecular genetic studies indicate that there are 15 types of bipolar cell in mouse retina (Shekhar et al., 2016). The present detailed study of more than 800 bipolar cells in ten Golgi-impregnated rabbit retinas indicates that there are 14-16 types of cone bipolar cell and one type of rod bipolar cell in rabbit retina. These have been carefully analyzed in terms of dendritic and axonal morphology, and axon terminal stratification with respect to fiducial starburst amacrine cells. In fortuitous proximity, several types of bipolar cell can be related to identified ganglion cells by stratification and by contacts suggestive of synaptic connection. These results are compared with other studies of rabbit bipolar cells. Homologies with bipolar cells of mouse and monkey are considered in functional terms.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Funding Information: U.S.P.H.S. Award R01EY03547, Alfred P. Sloan Foundation, Alberta Heritage Foundation for Medical Research, Medical Research Council of Canada, Natural Sciences and Engineering Research Council of Canada.
Addition of Table 3, revision of Figure 36, revision of figure legends of figures 36 and 37, with minor revisions of comparative section of discussion.