High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer

Yushu Ma; Chien-Hung Shih; Jinxiong Cheng; Hsiao-Chun Chen; Li-Ju Wang; Yanhao Tan; Yu-Chiao Chiu; Yu-Chih Chen

doi:10.1101/2024.09.23.614522

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High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer

Yushu Ma, Chien-Hung Shih, Jinxiong Cheng, Hsiao-Chun Chen, Li-Ju Wang, Yanhao Tan, View ORCID ProfileYu-Chiao Chiu, Yu-Chih Chen

doi: https://doi.org/10.1101/2024.09.23.614522

Yushu Ma

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

bDepartment of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15260, USA

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Chien-Hung Shih

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

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Jinxiong Cheng

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

cDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O’Hara Street, Pittsburgh, PA 15260, USA

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Hsiao-Chun Chen

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

bDepartment of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15260, USA

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Li-Ju Wang

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

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Yanhao Tan

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

dDivision of Malignant Hematology and Medical Oncology, Department of Medicine, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, PA 15232, USA

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Yu-Chiao Chiu

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

bDepartment of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15260, USA

dDivision of Malignant Hematology and Medical Oncology, Department of Medicine, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, PA 15232, USA

eCMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15260, USA

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ORCID record for Yu-Chiao Chiu
For correspondence: YUC250@pitt.edu cheny25@upmc.edu

Yu-Chih Chen

aUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA

bDepartment of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15260, USA

cDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O’Hara Street, Pittsburgh, PA 15260, USA

eCMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15260, USA

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For correspondence: YUC250@pitt.edu cheny25@upmc.edu

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High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer

Yushu Ma, Chien-Hung Shih, Jinxiong Cheng, Hsiao-Chun Chen, Li-Ju Wang, Yanhao Tan, Yu-Chiao Chiu, Yu-Chih Chen

bioRxiv 2024.09.23.614522; doi: https://doi.org/10.1101/2024.09.23.614522

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High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer

Yushu Ma, Chien-Hung Shih, Jinxiong Cheng, Hsiao-Chun Chen, Li-Ju Wang, Yanhao Tan, Yu-Chiao Chiu, Yu-Chih Chen

bioRxiv 2024.09.23.614522; doi: https://doi.org/10.1101/2024.09.23.614522

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