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A Novel Engineered U7 Small Nuclear RNA Scaffold Greatly Increases in vitro and in vivo ADAR-Mediated Programmable RNA Base Editing
View ORCID ProfileSusan M. Byrne, Stephen M. Burleigh, View ORCID ProfileRobert Fragoza, View ORCID ProfileYue Jiang, Yiannis Savva, Ricky Pabon, View ORCID ProfileJoseph Rainaldi, View ORCID ProfileAndrew Portell, Prashant Mali, Adrian W. Briggs
doi: https://doi.org/10.1101/2024.09.29.615721
Susan M. Byrne
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
Stephen M. Burleigh
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
Robert Fragoza
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
Yue Jiang
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
Yiannis Savva
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
Ricky Pabon
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
Joseph Rainaldi
2University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA
Andrew Portell
2University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA
Prashant Mali
2University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA
Adrian W. Briggs
1Shape Therapeutics, 700 Dexter Avenue North, Seattle, WA, 98109, USA
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Posted October 01, 2024.
A Novel Engineered U7 Small Nuclear RNA Scaffold Greatly Increases in vitro and in vivo ADAR-Mediated Programmable RNA Base Editing
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs
bioRxiv 2024.09.29.615721; doi: https://doi.org/10.1101/2024.09.29.615721
A Novel Engineered U7 Small Nuclear RNA Scaffold Greatly Increases in vitro and in vivo ADAR-Mediated Programmable RNA Base Editing
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs
bioRxiv 2024.09.29.615721; doi: https://doi.org/10.1101/2024.09.29.615721
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