The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

Morgane Mermet; Jessica Denom; Aleksandra Mieczkowska; Emma Biggs; Fiona M. Gribble; Frank Reimann; Christophe Magnan; Celine Cruciani-Guglielmacci; Guillaume Mabilleau

doi:10.1101/2024.10.05.616809

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The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

Morgane Mermet, Jessica Denom, Aleksandra Mieczkowska, Emma Biggs, Fiona M. Gribble, Frank Reimann, Christophe Magnan, Celine Cruciani-Guglielmacci, Guillaume Mabilleau

doi: https://doi.org/10.1101/2024.10.05.616809

Morgane Mermet

1Univ Angers, Nantes Université, ONIRIS, Inserm, RMeS, UMR 1229, SFR ICAT, F-49000, Angers, France

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Jessica Denom

2Université Paris Cité, CNRS, BFA, UMR 8251, F-75205, Paris, France

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Aleksandra Mieczkowska

1Univ Angers, Nantes Université, ONIRIS, Inserm, RMeS, UMR 1229, SFR ICAT, F-49000, Angers, France

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Emma Biggs

3Institute of Metabolic Science & MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, UK

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Fiona M. Gribble

3Institute of Metabolic Science & MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, UK

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Frank Reimann

3Institute of Metabolic Science & MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, UK

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Christophe Magnan

2Université Paris Cité, CNRS, BFA, UMR 8251, F-75205, Paris, France

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Celine Cruciani-Guglielmacci

2Université Paris Cité, CNRS, BFA, UMR 8251, F-75205, Paris, France

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Guillaume Mabilleau

1Univ Angers, Nantes Université, ONIRIS, Inserm, RMeS, UMR 1229, SFR ICAT, F-49000, Angers, France

4CHU Angers, Departement de Pathologie Cellulaire et Tissulaire, UF de Pathologie osseuse, 49933 Angers, France

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For correspondence: [email protected]

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The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

Morgane Mermet, Jessica Denom, Aleksandra Mieczkowska, Emma Biggs, Fiona M. Gribble, Frank Reimann, Christophe Magnan, Celine Cruciani-Guglielmacci, Guillaume Mabilleau

bioRxiv 2024.10.05.616809; doi: https://doi.org/10.1101/2024.10.05.616809

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The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

Morgane Mermet, Jessica Denom, Aleksandra Mieczkowska, Emma Biggs, Fiona M. Gribble, Frank Reimann, Christophe Magnan, Celine Cruciani-Guglielmacci, Guillaume Mabilleau

bioRxiv 2024.10.05.616809; doi: https://doi.org/10.1101/2024.10.05.616809

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