Deciphering Ca2+ Permeation and Valence Selectivity in CaV1: Molecular Dynamics Simulations Reveal the Three-Ion Knock-on Mechanism

Lingfeng Xue; Nieng Yan; Chen Song

doi:10.1101/2024.11.27.625788

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Deciphering Ca²⁺ Permeation and Valence Selectivity in Ca_V1: Molecular Dynamics Simulations Reveal the Three-Ion Knock-on Mechanism

View ORCID ProfileLingfeng Xue, View ORCID ProfileNieng Yan, View ORCID ProfileChen Song

doi: https://doi.org/10.1101/2024.11.27.625788

Lingfeng Xue

1Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

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Nieng Yan

2Institute of Bio-Architecture and Bio-Interactions (IBABI), Shenzhen Medical Academy of Research and Translation (SMART), Shenzhen, Guangdong, China

3Beijing Frontier Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, State Key Laboratory of Membrane Biology, Tsinghua University, Beijing, China

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Chen Song

1Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

4Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

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ORCID record for Chen Song
For correspondence: c.song@pku.edu.cn

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Deciphering Ca²⁺ Permeation and Valence Selectivity in Ca_V1: Molecular Dynamics Simulations Reveal the Three-Ion Knock-on Mechanism

Lingfeng Xue, Nieng Yan, Chen Song

bioRxiv 2024.11.27.625788; doi: https://doi.org/10.1101/2024.11.27.625788

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Deciphering Ca²⁺ Permeation and Valence Selectivity in Ca_V1: Molecular Dynamics Simulations Reveal the Three-Ion Knock-on Mechanism

Lingfeng Xue, Nieng Yan, Chen Song

bioRxiv 2024.11.27.625788; doi: https://doi.org/10.1101/2024.11.27.625788

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