Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids

Ioritz Sorzabal; Xabier Morales; Iván Cortés-Domínguez; Maider Esparza; Lucía Grande; Pedro Castillo; Shruthi Narayanan; Mariano Ponz-Sarvise; Silvestre Vicent; Carlos Ortiz-de-Solórzano

doi:10.1101/2024.12.31.630904

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Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids

View ORCID ProfileIoritz Sorzabal, View ORCID ProfileXabier Morales, Iván Cortés-Domínguez, View ORCID ProfileMaider Esparza, Lucía Grande, Pedro Castillo, View ORCID ProfileShruthi Narayanan, View ORCID ProfileMariano Ponz-Sarvise, View ORCID ProfileSilvestre Vicent, View ORCID ProfileCarlos Ortiz-de-Solórzano

doi: https://doi.org/10.1101/2024.12.31.630904

Ioritz Sorzabal

1Program in Biomedical Engineering, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

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Xabier Morales

2Imaging Platform, CIMA Universidad de Navarra, Pamplona. Spain

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Iván Cortés-Domínguez

1Program in Biomedical Engineering, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

2Imaging Platform, CIMA Universidad de Navarra, Pamplona. Spain

3Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona. Spain

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Maider Esparza

2Imaging Platform, CIMA Universidad de Navarra, Pamplona. Spain

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Lucía Grande

2Imaging Platform, CIMA Universidad de Navarra, Pamplona. Spain

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Pedro Castillo

1Program in Biomedical Engineering, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

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Shruthi Narayanan

4Program in Solid Tumors, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

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Mariano Ponz-Sarvise

5Department of Medical Oncology and Program in Solid Tumors, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

7Navarra Health Institute (IDISNA), Pamplona, Spain

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Silvestre Vicent

4Program in Solid Tumors, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

6Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain

7Navarra Health Institute (IDISNA), Pamplona, Spain

8University of Navarra, Department of Pathology, Anatomy and Physiology, Pamplona, Spain

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Carlos Ortiz-de-Solórzano

1Program in Biomedical Engineering, CIMA Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain

2Imaging Platform, CIMA Universidad de Navarra, Pamplona. Spain

6Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain

9University of Navarra, Department of Biomedical Enginerring, TECNUN, San Sebastián, Spain

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For correspondence: [email protected]

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Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids

Ioritz Sorzabal, Xabier Morales, Iván Cortés-Domínguez, Maider Esparza, Lucía Grande, Pedro Castillo, Shruthi Narayanan, Mariano Ponz-Sarvise, Silvestre Vicent, Carlos Ortiz-de-Solórzano

bioRxiv 2024.12.31.630904; doi: https://doi.org/10.1101/2024.12.31.630904

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Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids

Ioritz Sorzabal, Xabier Morales, Iván Cortés-Domínguez, Maider Esparza, Lucía Grande, Pedro Castillo, Shruthi Narayanan, Mariano Ponz-Sarvise, Silvestre Vicent, Carlos Ortiz-de-Solórzano

bioRxiv 2024.12.31.630904; doi: https://doi.org/10.1101/2024.12.31.630904

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