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Helical transition of the bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation
View ORCID ProfileChhandosee Ganguly, Lindsie Martin, View ORCID ProfileSwarmistha Aribam, Leonard M. Thomas, View ORCID ProfileRakhi Rajan
doi: https://doi.org/10.1101/2025.01.09.632262
Chhandosee Ganguly
1Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA
Lindsie Martin
1Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA
Swarmistha Aribam
1Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA
Leonard M. Thomas
1Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA
Rakhi Rajan
1Department of Chemistry and Biochemistry, Price Family Foundation Institute of Structural Biology, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA

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Posted January 10, 2025.
Helical transition of the bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation
Chhandosee Ganguly, Lindsie Martin, Swarmistha Aribam, Leonard M. Thomas, Rakhi Rajan
bioRxiv 2025.01.09.632262; doi: https://doi.org/10.1101/2025.01.09.632262
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