Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

Julia Su; Rohan Gupta; Scott Van Hoof; Jakob Kreye; Harald Prüss; Benjamin Spielman; Lior Brimberg; Bruce T. Volpe; Patricio T. Huerta; Betty Diamond

doi:10.1101/2025.01.16.633238

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Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

Julia Su, Rohan Gupta, Scott Van Hoof, Jakob Kreye, Harald Prüss, Benjamin Spielman, Lior Brimberg, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond

doi: https://doi.org/10.1101/2025.01.16.633238

Julia Su

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

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Rohan Gupta

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

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Scott Van Hoof

2German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany

3Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, Berlin, Germany

4Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), Berlin, Germany

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Jakob Kreye

2German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany

3Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, Berlin, Germany

4Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), Berlin, Germany

5Department of Pediatric Neurology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Harald Prüss

2German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany

3Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, Berlin, Germany

4Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), Berlin, Germany

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Benjamin Spielman

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

9Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

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Lior Brimberg

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

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Bruce T. Volpe

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

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Patricio T. Huerta

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

7Laboratory of Immune & Neural Networks, Feinstein Institutes for Medical Research, Manhasset, NY, USA

8Elmezzi Graduate School of Molecular Medicine at Northwell Health, Manhasset, NY, USA

9Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

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Betty Diamond

1Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

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For correspondence: [email protected]

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Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

Julia Su, Rohan Gupta, Scott Van Hoof, Jakob Kreye, Harald Prüss, Benjamin Spielman, Lior Brimberg, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond

bioRxiv 2025.01.16.633238; doi: https://doi.org/10.1101/2025.01.16.633238

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Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

Julia Su, Rohan Gupta, Scott Van Hoof, Jakob Kreye, Harald Prüss, Benjamin Spielman, Lior Brimberg, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond

bioRxiv 2025.01.16.633238; doi: https://doi.org/10.1101/2025.01.16.633238

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