IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy

Sofía Castelli; Wesley V. Wilson; Ugur Uslu; Amanda Finck; Charles-Antoine Assenmacher; Sebastian J. Atoche; Mikko Siurala; Regina M. Young; Carl H. June

doi:10.1101/2025.01.30.635582

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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy

Sofía Castelli, Wesley V. Wilson, Ugur Uslu, Amanda Finck, Charles-Antoine Assenmacher, Sebastian J. Atoche, Mikko Siurala, Regina M. Young, Carl H. June

doi: https://doi.org/10.1101/2025.01.30.635582

Sofía Castelli

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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Wesley V. Wilson

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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Ugur Uslu

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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Amanda Finck

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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Charles-Antoine Assenmacher

3Comparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

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Sebastian J. Atoche

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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Mikko Siurala

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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Regina M. Young

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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For correspondence: [email protected]

Carl H. June

1Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA

2Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, 19104, USA

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For correspondence: [email protected]

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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy

Sofía Castelli, Wesley V. Wilson, Ugur Uslu, Amanda Finck, Charles-Antoine Assenmacher, Sebastian J. Atoche, Mikko Siurala, Regina M. Young, Carl H. June

bioRxiv 2025.01.30.635582; doi: https://doi.org/10.1101/2025.01.30.635582

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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy

Sofía Castelli, Wesley V. Wilson, Ugur Uslu, Amanda Finck, Charles-Antoine Assenmacher, Sebastian J. Atoche, Mikko Siurala, Regina M. Young, Carl H. June

bioRxiv 2025.01.30.635582; doi: https://doi.org/10.1101/2025.01.30.635582

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