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An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses
Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Xiaotang Du, Alex Choi, Trevor Parry, Mayumi Naramura, Chen Chen, Stefanie Jaeger, Michael Shales, Dan A. Portnoy, Ryan Hernandez, Laurent Coscoy, Jeffery S. Cox, Nevan J. Krogan
doi: https://doi.org/10.1101/202598
Bennett H. Penn
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Zoe Netter
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Jeffrey R. Johnson
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
John Von Dollen
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
Gwendolyn M. Jang
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
Tasha Johnson
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
Yamini M. Ohol
3Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94158, USA.
Cyrus Maher
4Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Samantha L. Bell
3Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94158, USA.
Kristina Geiger
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Xiaotang Du
3Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94158, USA.
Alex Choi
3Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94158, USA.
Trevor Parry
3Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, CA 94158, USA.
Mayumi Naramura
5Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska, Omaha, NE 68182, USA.
Chen Chen
7School of Public Health, University of California, Berkeley, Berkeley, CA 94720
Stefanie Jaeger
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
Michael Shales
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
Dan A. Portnoy
7School of Public Health, University of California, Berkeley, Berkeley, CA 94720
Ryan Hernandez
4Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Laurent Coscoy
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Jeffery S. Cox
1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Nevan J. Krogan
2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA, QBI, Quantitative Biosciences Institute, University of California, San Francisco, CA 94148, USA; Gladstone Institutes, San Francisco, CA 94158, USA.
Article usage
Posted October 13, 2017.
An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses
Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Xiaotang Du, Alex Choi, Trevor Parry, Mayumi Naramura, Chen Chen, Stefanie Jaeger, Michael Shales, Dan A. Portnoy, Ryan Hernandez, Laurent Coscoy, Jeffery S. Cox, Nevan J. Krogan
bioRxiv 202598; doi: https://doi.org/10.1101/202598
An Mtb-Human Protein-Protein Interaction Map Reveals that Bacterial LpqN Antagonizes CBL, a Host Ubiquitin Ligase that Regulates the Balance Between Anti-Viral and Anti-Bacterial Responses
Bennett H. Penn, Zoe Netter, Jeffrey R. Johnson, John Von Dollen, Gwendolyn M. Jang, Tasha Johnson, Yamini M. Ohol, Cyrus Maher, Samantha L. Bell, Kristina Geiger, Xiaotang Du, Alex Choi, Trevor Parry, Mayumi Naramura, Chen Chen, Stefanie Jaeger, Michael Shales, Dan A. Portnoy, Ryan Hernandez, Laurent Coscoy, Jeffery S. Cox, Nevan J. Krogan
bioRxiv 202598; doi: https://doi.org/10.1101/202598
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