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Using experience to improve: How errors shape behavior and brain activity in monkeys

View ORCID ProfileJose L. Pardo-Vazquez, Carlos Acuña
doi: https://doi.org/10.1101/203737
Jose L. Pardo-Vazquez
1Laboratorios de Neurociencia, Facultad de Medicina, Universidad de Santiago de Compostela. 15705, Santiago de Compostela, Spain
2Circuit Dynamics and Computation Laboratory, Champalimaud Centre for the Unknown, Lisbon, Portugal
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Carlos Acuña
1Laboratorios de Neurociencia, Facultad de Medicina, Universidad de Santiago de Compostela. 15705, Santiago de Compostela, Spain
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Abstract

Previous works have shown that neurons from the ventral premotor cortex (PMv) represent several elements of perceptual decisions. One of the most striking findings was that, after the outcome of the choice is known, neurons from PMv encode all the information necessary for evaluating the decision process. These results prompted us to suggest that this cortical area could be involved in shaping future behavior. In this work, we have characterized neuronal activity and behavioral performance as a function of the outcome of the previous trial. We found that the outcome of the immediately previous trial (n-1) significantly changes, in the current trial (n), the activity of single cells and behavioral performance. The outcome of trial n-2, however, does not affect either behavior or neuronal activity. Moreover, the outcome of difficult trials had a greater impact on performance and recruited more PMv neurons than the outcome of easy trials. These results give strong support to our suggestion that PMv neurons evaluate the decision process and use this information to modify future behavior.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 16, 2017.
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Using experience to improve: How errors shape behavior and brain activity in monkeys
Jose L. Pardo-Vazquez, Carlos Acuña
bioRxiv 203737; doi: https://doi.org/10.1101/203737
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Using experience to improve: How errors shape behavior and brain activity in monkeys
Jose L. Pardo-Vazquez, Carlos Acuña
bioRxiv 203737; doi: https://doi.org/10.1101/203737

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