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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Yakir A Reshef, Hilary K Finucane, David R Kelley, Alexander Gusev, Dylan Kotliar, Jacob C Ulirsch, Farhad Hormozdiari, Joseph Nasser, Luke O’Connor, Bryce van de Geijn, Po-Ru Loh, Shari Grossman, Gaurav Bhatia, Steven Gazal, Pier Francesco Palamara, Luca Pinello, Nick Patterson, Ryan P Adams, Alkes L Price
doi: https://doi.org/10.1101/204685
Yakir A Reshef
1Department of Computer Science, Harvard University, Cambridge, MA
2Harvard/MIT MD/PhD Program, Boston, MA
3Broad Institute of MIT and Harvard, Cambridge, MA
Hilary K Finucane
3Broad Institute of MIT and Harvard, Cambridge, MA
David R Kelley
4California Life Sciences Company, South San Francisco, CA
Alexander Gusev
5Dana Farber Cancer Institute, Boston, MA
Dylan Kotliar
3Broad Institute of MIT and Harvard, Cambridge, MA
Jacob C Ulirsch
3Broad Institute of MIT and Harvard, Cambridge, MA
5Dana Farber Cancer Institute, Boston, MA
6Boston Children’s Hospital, Boston, MA
Farhad Hormozdiari
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Joseph Nasser
3Broad Institute of MIT and Harvard, Cambridge, MA
Luke O’Connor
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
8Program in Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA
Bryce van de Geijn
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Po-Ru Loh
9Brigham and Women’s Hospital, Boston, MA
Shari Grossman
3Broad Institute of MIT and Harvard, Cambridge, MA
Gaurav Bhatia
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Steven Gazal
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Pier Francesco Palamara
3Broad Institute of MIT and Harvard, Cambridge, MA
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
10Department of Statistics, University of Oxford, Oxford, UK
Luca Pinello
11The Massachusetts General Hospital, Boston, MA
Nick Patterson
3Broad Institute of MIT and Harvard, Cambridge, MA
Ryan P Adams
12Google Brain, New York, NY
13Department of Computer Science, Princeton University, Princeton, NJ
Alkes L Price
7Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
14Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA
Article usage
Posted May 04, 2018.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Yakir A Reshef, Hilary K Finucane, David R Kelley, Alexander Gusev, Dylan Kotliar, Jacob C Ulirsch, Farhad Hormozdiari, Joseph Nasser, Luke O’Connor, Bryce van de Geijn, Po-Ru Loh, Shari Grossman, Gaurav Bhatia, Steven Gazal, Pier Francesco Palamara, Luca Pinello, Nick Patterson, Ryan P Adams, Alkes L Price
bioRxiv 204685; doi: https://doi.org/10.1101/204685
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Yakir A Reshef, Hilary K Finucane, David R Kelley, Alexander Gusev, Dylan Kotliar, Jacob C Ulirsch, Farhad Hormozdiari, Joseph Nasser, Luke O’Connor, Bryce van de Geijn, Po-Ru Loh, Shari Grossman, Gaurav Bhatia, Steven Gazal, Pier Francesco Palamara, Luca Pinello, Nick Patterson, Ryan P Adams, Alkes L Price
bioRxiv 204685; doi: https://doi.org/10.1101/204685
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