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Predicting the genetic loci of past evolution

View ORCID ProfileVirginie Courtier-Orgogozo, View ORCID ProfileArnaud Martin
doi: https://doi.org/10.1101/205153
Virginie Courtier-Orgogozo
Institut Jacques Monod;
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  • For correspondence: virginie.courtier@ijm.fr
Arnaud Martin
The George Washington University
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Abstract

Repetitions in the mutations found to be responsible for independent evolution of similar phenotypes in various taxa have led some biologists to propose that for certain evolutionary changes the causal mutations are predictable. We examine here the nature of the predictions that have been made and their associated arguments. Predictions about the loci of past evolution are retrodictions, i.e. inferences about events that occurred in the past. They are not based on elaborate models and they derive mainly from the observation of repeated cases of genetic evolution. Predictions at the nucleotide level or at the gene level have a higher inference gain than those for broader categories of genetic changes such as cis-regulatory mutations.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 19, 2017.
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Predicting the genetic loci of past evolution
Virginie Courtier-Orgogozo, Arnaud Martin
bioRxiv 205153; doi: https://doi.org/10.1101/205153
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Predicting the genetic loci of past evolution
Virginie Courtier-Orgogozo, Arnaud Martin
bioRxiv 205153; doi: https://doi.org/10.1101/205153

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