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Specific hippocampal representations are linked to generalized cortical representations in memory

Jai Y. Yu, Daniel F. Liu, Adrianna Loback, Irene Grossrubatscher, Loren M. Frank
doi: https://doi.org/10.1101/207142
Jai Y. Yu
1UCSF Center for Integrative Neuroscience and Department of Physiology, University of California San Francisco, California, United States of America
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Daniel F. Liu
2University of California Berkeley, Berkeley, California, United States of America
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Adrianna Loback
3Princeton University, Princeton, New Jersey, United States of America
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Irene Grossrubatscher
2University of California Berkeley, Berkeley, California, United States of America
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Loren M. Frank
1UCSF Center for Integrative Neuroscience and Department of Physiology, University of California San Francisco, California, United States of America
4Howard Hughes Medical Institute, University of California, San Francisco, California, United States of America
5Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, California, United States of America
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  • For correspondence: loren@phy.ucsf.edu
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Summary

Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences, but how neuronal activity patterns support this link is not known. Here we show that during memory reactivation in a foraging task with multiple spatial paths, specific hippocampal place representations are concurrently and preferentially reactivated with a subset of prefrontal cortical task representations that generalize across different paths. This link between specific and general representations may serve as a neural substrate for abstraction and task guidance in mammals.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 21, 2017.
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Specific hippocampal representations are linked to generalized cortical representations in memory
Jai Y. Yu, Daniel F. Liu, Adrianna Loback, Irene Grossrubatscher, Loren M. Frank
bioRxiv 207142; doi: https://doi.org/10.1101/207142
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Specific hippocampal representations are linked to generalized cortical representations in memory
Jai Y. Yu, Daniel F. Liu, Adrianna Loback, Irene Grossrubatscher, Loren M. Frank
bioRxiv 207142; doi: https://doi.org/10.1101/207142

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