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Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum

Amélie Vantaux, Franck Yao, Domonbabele FdS Hien, Edwige Guissou, Bienvenue K. Yameogo, Louis-Clément Gouagna, Didier Fontenille, François Renaud, Frédéric Simard, Carlo Costantini, Fréderic Thomas, Karine Mouline, Benjamin Roche, Anna Cohuet, Kounbobr R. Dabiré, Thierry Lefèvre
doi: https://doi.org/10.1101/207183
Amélie Vantaux
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
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Franck Yao
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
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Domonbabele FdS Hien
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
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Edwige Guissou
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
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Bienvenue K. Yameogo
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
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Louis-Clément Gouagna
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
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Didier Fontenille
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
dInstitut Pasteur in Cambodia, Phnom Penh, Cambodia
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François Renaud
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
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Frédéric Simard
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
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Carlo Costantini
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
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Fréderic Thomas
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
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Karine Mouline
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
cLaboratoire mixte international sur les vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso
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Benjamin Roche
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
eUnité de Modélisation Mathématique et Informatique des Systèmes complexes (UMMISCO), UMI IRD/UPMC209, Bondy, France
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Anna Cohuet
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
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Kounbobr R. Dabiré
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
cLaboratoire mixte international sur les vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso
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Thierry Lefèvre
aMaladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle (MIVEGEC), UMR IRD 224-CNRS 5290-UM, Montpellier, France
bInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso
cLaboratoire mixte international sur les vecteurs (LAMIVECT), Bobo Dioulasso, Burkina Faso
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Abstract

Whether the malaria parasite Plasmodium falciparum can manipulate mosquito host choice in ways that enhance parasite transmission toward human is unknown. We assessed the influence of P. falciparum on the blood-feeding behaviour of three of its major vectors (Anopheles coluzzii, An. gambiae and An. arabiensis) in Burkina Faso. Host preferences assays using odor-baited traps revealed no effect of infection on mosquito long-range anthropophily. However, the identification of the blood meal origin of mosquitoes showed that females carrying sporozoites, the mature transmissible stage of the parasite, were 24% more anthropophagic than both females harbouring oocysts, the parasite immature stage, and uninfected individuals. Using a mathematical model, we further show that this increased anthropophagy in infectious females can have important epidemiological consequences with up to 123% increase in parasite transmission at low mosquito to human ratios. This increase in transmission potential highlights the importance of vector control tools targeting infectious females.

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Posted October 21, 2017.
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Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum
Amélie Vantaux, Franck Yao, Domonbabele FdS Hien, Edwige Guissou, Bienvenue K. Yameogo, Louis-Clément Gouagna, Didier Fontenille, François Renaud, Frédéric Simard, Carlo Costantini, Fréderic Thomas, Karine Mouline, Benjamin Roche, Anna Cohuet, Kounbobr R. Dabiré, Thierry Lefèvre
bioRxiv 207183; doi: https://doi.org/10.1101/207183
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Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum
Amélie Vantaux, Franck Yao, Domonbabele FdS Hien, Edwige Guissou, Bienvenue K. Yameogo, Louis-Clément Gouagna, Didier Fontenille, François Renaud, Frédéric Simard, Carlo Costantini, Fréderic Thomas, Karine Mouline, Benjamin Roche, Anna Cohuet, Kounbobr R. Dabiré, Thierry Lefèvre
bioRxiv 207183; doi: https://doi.org/10.1101/207183

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