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Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
View ORCID ProfileWei Zhou, View ORCID ProfileJonas B. Nielsen, View ORCID ProfileLars G. Fritsche, Rounak Dey, Maiken B. Elvestad, View ORCID ProfileBrooke N. Wolford, Jonathon LeFaive, Peter VandeHaar, Aliya Gifford, Lisa A. Bastarache, Wei-Qi Wei, Joshua C. Denny, Maoxuan Lin, Kristian Hveem, Hyun Min Kang, Goncalo R. Abecasis, View ORCID ProfileCristen J. Wilier, View ORCID ProfileSeunggeun Lee
doi: https://doi.org/10.1101/212357
Wei Zhou
1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Jonas B. Nielsen
3Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor MI 48109, USA
Lars G. Fritsche
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, 7491 Trondheim, Sør-Trøndelag, Norway
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Rounak Dey
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Maiken B. Elvestad
4K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, 7491 Trondheim, Sør-Trøndelag, Norway
Brooke N. Wolford
1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Jonathon LeFaive
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Peter VandeHaar
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Aliya Gifford
6Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
Lisa A. Bastarache
6Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
Wei-Qi Wei
6Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
Joshua C. Denny
6Departments of Biomedical Informatics, Vanderbilt University, Nashville, TN 37232, USA
7Departments of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Maoxuan Lin
3Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor MI 48109, USA
Kristian Hveem
8HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway
9Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, 7600 Levanger, Norway
Hyun Min Kang
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Goncalo R. Abecasis
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Cristen J. Wilier
1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
3Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor MI 48109, USA
10Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Seunggeun Lee
2Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
5Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Article usage
Posted November 24, 2017.
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
Wei Zhou, Jonas B. Nielsen, Lars G. Fritsche, Rounak Dey, Maiken B. Elvestad, Brooke N. Wolford, Jonathon LeFaive, Peter VandeHaar, Aliya Gifford, Lisa A. Bastarache, Wei-Qi Wei, Joshua C. Denny, Maoxuan Lin, Kristian Hveem, Hyun Min Kang, Goncalo R. Abecasis, Cristen J. Wilier, Seunggeun Lee
bioRxiv 212357; doi: https://doi.org/10.1101/212357
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
Wei Zhou, Jonas B. Nielsen, Lars G. Fritsche, Rounak Dey, Maiken B. Elvestad, Brooke N. Wolford, Jonathon LeFaive, Peter VandeHaar, Aliya Gifford, Lisa A. Bastarache, Wei-Qi Wei, Joshua C. Denny, Maoxuan Lin, Kristian Hveem, Hyun Min Kang, Goncalo R. Abecasis, Cristen J. Wilier, Seunggeun Lee
bioRxiv 212357; doi: https://doi.org/10.1101/212357
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