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Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes

Molly Schumer, Chenling Xu, Daniel L. Powell, Arun Durvasula, Laurits Skov, Chris Holland, Sriram Sankararaman, Peter Andolfatto, Gil G. Rosenthal, Molly Przeworski
doi: https://doi.org/10.1101/212407
Molly Schumer
1Hanna H. Gray Fellow, Howard Hughes Medical Institute
2Harvard Society of Fellows, Harvard University
3Department of Biological Sciences, Columbia University
4Centro de Investigaciones Científicas de las Huastecas “Aguazarca”
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  • For correspondence: schumer@fas.harvard.edu mp3284@columbia.edu
Chenling Xu
5Center for Computational Biology, University of California at Berkeley
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Daniel L. Powell
4Centro de Investigaciones Científicas de las Huastecas “Aguazarca”
6Department of Biology, Texas A&M University
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Arun Durvasula
7Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
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Laurits Skov
8Bioinformatics Research Centre, Aarhus University, Aarhus C., Denmark
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Chris Holland
4Centro de Investigaciones Científicas de las Huastecas “Aguazarca”
6Department of Biology, Texas A&M University
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Sriram Sankararaman
7Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
9Department of Computer Science, University of California, Los Angeles
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Peter Andolfatto
10Department of Ecology and Evolutionary Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University
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Gil G. Rosenthal
4Centro de Investigaciones Científicas de las Huastecas “Aguazarca”
6Department of Biology, Texas A&M University
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Molly Przeworski
3Department of Biological Sciences, Columbia University
11Department of Systems Biology, Columbia University
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Abstract

While hybridization between species is increasingly appreciated to be a common occurrence, little is known about the forces that govern the subsequent evolution of hybrid genomes. We considered this question in three independent, naturally-occurring hybrid populations formed between swordtail fish species Xiphophorus birchmanni and X. malinche. To this end, we built a fine-scale genetic map and inferred patterns of local ancestry along the genomes of 690 individuals sampled from the three populations. In all three cases, we found hybrid ancestry to be more common in regions of high recombination and where there is linkage to fewer putative targets of selection. These same patterns are also apparent in a reanalysis of human-Neanderthal admixture. Our results lend support to models in which ancestry from the “minor” parental species persists only where it is rapidly uncoupled from alleles that are deleterious in hybrids, and show the retention of hybrid ancestry to be at least in part predictable from genomic features. Our analyses further indicate that in swordtail fish, the dominant source of selection on hybrids stems from deleterious combinations of epistatically-interacting alleles.

One sentence summary The persistence of hybrid ancestry is predictable from local recombination rates, in three replicate hybrid populations as well as in humans.

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Posted November 01, 2017.
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Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes
Molly Schumer, Chenling Xu, Daniel L. Powell, Arun Durvasula, Laurits Skov, Chris Holland, Sriram Sankararaman, Peter Andolfatto, Gil G. Rosenthal, Molly Przeworski
bioRxiv 212407; doi: https://doi.org/10.1101/212407
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Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes
Molly Schumer, Chenling Xu, Daniel L. Powell, Arun Durvasula, Laurits Skov, Chris Holland, Sriram Sankararaman, Peter Andolfatto, Gil G. Rosenthal, Molly Przeworski
bioRxiv 212407; doi: https://doi.org/10.1101/212407

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