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Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumour DNA sequencing
Sonia Mansukhani, Louise J. Barber, Sing Yu Moorcraft, Michael Davidson, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Bram Herman, Nik Matthews, Ben O’Leary, Sanna Hulkki, David Gonzalez De Castro, Michael Hubank, Anisha Patel, Andrew Wotherspoon, Aleruchi Okachi, Isma Rana, Ruwaida Begum, Matthew Davies, Thomas Powles, Katharina von Loga, Nick Turner, David Watkins, Ian Chau, David Cunningham, Naureen Starling, View ORCID ProfileMarco Gerlinger
doi: https://doi.org/10.1101/213306
Sonia Mansukhani
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
Louise J. Barber
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
Sing Yu Moorcraft
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Michael Davidson
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Andrew Woolston
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
Beatrice Griffiths
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
Kerry Fenwick
3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom.
Bram Herman
4Diagnostics and Genomics Group, Agilent Technologies Inc., Santa Clara, USA
Nik Matthews
3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom.
Ben O’Leary
5Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom.
Sanna Hulkki
6Centre for Molecular Pathology, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.
David Gonzalez De Castro
7Centre for Cancer Research and Cell Biology, Belfast, United Kingdom.
Michael Hubank
6Centre for Molecular Pathology, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.
Anisha Patel
8Department for Radiology, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Andrew Wotherspoon
9Department of Histopathology, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Aleruchi Okachi
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Isma Rana
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Ruwaida Begum
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Matthew Davies
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
10Current address: Achilles Therapeutics, Francis Crick Institute, London, United Kingdom.
Thomas Powles
11Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
Katharina von Loga
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
Nick Turner
5Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom.
12Breast Cancer Unit, The Royal Marsden NHS Foundation Trust
David Watkins
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Ian Chau
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
David Cunningham
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Naureen Starling
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Marco Gerlinger
1Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.
2Gastrointestinal Cancer Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, United Kingdom.
Article usage
Posted November 02, 2017.
Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumour DNA sequencing
Sonia Mansukhani, Louise J. Barber, Sing Yu Moorcraft, Michael Davidson, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Bram Herman, Nik Matthews, Ben O’Leary, Sanna Hulkki, David Gonzalez De Castro, Michael Hubank, Anisha Patel, Andrew Wotherspoon, Aleruchi Okachi, Isma Rana, Ruwaida Begum, Matthew Davies, Thomas Powles, Katharina von Loga, Nick Turner, David Watkins, Ian Chau, David Cunningham, Naureen Starling, Marco Gerlinger
bioRxiv 213306; doi: https://doi.org/10.1101/213306
Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumour DNA sequencing
Sonia Mansukhani, Louise J. Barber, Sing Yu Moorcraft, Michael Davidson, Andrew Woolston, Beatrice Griffiths, Kerry Fenwick, Bram Herman, Nik Matthews, Ben O’Leary, Sanna Hulkki, David Gonzalez De Castro, Michael Hubank, Anisha Patel, Andrew Wotherspoon, Aleruchi Okachi, Isma Rana, Ruwaida Begum, Matthew Davies, Thomas Powles, Katharina von Loga, Nick Turner, David Watkins, Ian Chau, David Cunningham, Naureen Starling, Marco Gerlinger
bioRxiv 213306; doi: https://doi.org/10.1101/213306
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