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Acute memory deficits in chemotherapy-treated adults

Oana C. Lindner, Andrew Mayes, Martin G. McCabe, Deborah Talmi
doi: https://doi.org/10.1101/215731
Oana C. Lindner
aDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Zochonis building, Oxford Road, Manchester, M139PL.
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  • For correspondence: o.c.lindner@leeds.ac.uk
Andrew Mayes
aDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Zochonis building, Oxford Road, Manchester, M139PL.
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Martin G. McCabe
bDivision of Molecular & Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
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Deborah Talmi
aDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Zochonis building, Oxford Road, Manchester, M139PL.
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Abstract

Data from research on amnesia and epilepsy are equivocal with regards to the dissociation, shown in animal models, between rapid and slow long-term memory consolidation. Cancer treatments have lasting disruptive effects on memory and on brain structures associated with memory, but their acute effects on synaptic consolidation are unknown. We investigated the hypothesis that cancer treatment selectively impairs slow synaptic consolidation. Cancer patients and their matched controls were administered a novel list-learning task modelled on the Rey Auditory-Verbal Learning Test. Learning, forgetting, and retrieval were tested before, and one day after patients’ first chemotherapy treatment. Due to difficulties recruiting cancer patients at that sensitive time, we were only able to study 10 patients and their matched controls. Patients exhibited treatment-dependent accelerated forgetting over 24 hours compared to their own pre-treatment performance and to the performance of control participants, in agreement with our hypothesis. The number of intrusions increased after treatment, suggesting retrieval deficits. Future research with larger samples should adapt our methods to distinguish between consolidation and retrieval causes for treatment-dependent accelerated forgetting. The presence of significant accelerated forgetting in our small sample is indicative of a potentially large acute effect of chemotherapy treatment on forgetting, with potentially clinically-relevant implications.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted November 07, 2017.
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Acute memory deficits in chemotherapy-treated adults
Oana C. Lindner, Andrew Mayes, Martin G. McCabe, Deborah Talmi
bioRxiv 215731; doi: https://doi.org/10.1101/215731
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Acute memory deficits in chemotherapy-treated adults
Oana C. Lindner, Andrew Mayes, Martin G. McCabe, Deborah Talmi
bioRxiv 215731; doi: https://doi.org/10.1101/215731

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