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T helper cells modulate intestinal stem cell renewal and differentiation
Moshe Biton, Adam L. Haber, Semir Beyaz, Noga Rogel, Christopher Smillie, Karthik Shekhar, Alexandra Schnell, Zuojia Chen, Chuan Wu, Jose Ordovas-Montanes, David Alvarez, Rebecca H. Herbst, Itay Tirosh, Grace Burgin, Danielle Dionne, Michael E. Xifaras, Mei Zhang, Alex K. Shalek, Ulrich H. von Andrian, Daniel B. Graham, Orit Rozenblatt-Rosen, Hai Ning Shi, Vijay Kuchroo, Omer Yilmaz, Aviv Regev, Ramnik J. Xavier
doi: https://doi.org/10.1101/217133
Moshe Biton
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
2Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114, USA
Adam L. Haber
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Semir Beyaz
3The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, Massachusetts 02139, USA.
4Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Noga Rogel
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Christopher Smillie
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Karthik Shekhar
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Alexandra Schnell
5Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Zuojia Chen
5Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Chuan Wu
5Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jose Ordovas-Montanes
6Institute for Medical Engineering Science & Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
8Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
David Alvarez
9Department of Microbiology & Immunobiology and Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA.
Rebecca H. Herbst
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
10Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA
Itay Tirosh
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Grace Burgin
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Danielle Dionne
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Michael E. Xifaras
3The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, Massachusetts 02139, USA.
Mei Zhang
11Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Alex K. Shalek
6Institute for Medical Engineering Science & Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
8Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA
Ulrich H. von Andrian
9Department of Microbiology & Immunobiology and Center for Immune Imaging, Harvard Medical School, Boston, MA 02115, USA.
Daniel B. Graham
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Orit Rozenblatt-Rosen
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Hai Ning Shi
11Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Vijay Kuchroo
5Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Omer Yilmaz
3The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, Massachusetts 02139, USA.
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
12Departments of Pathology, Gastroenterology, and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Aviv Regev
1Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
3The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, Massachusetts 02139, USA.
13Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02140, USA
Ramnik J. Xavier
2Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, 02114, USA
7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
14Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, 02114, USA
Posted November 14, 2017.
T helper cells modulate intestinal stem cell renewal and differentiation
Moshe Biton, Adam L. Haber, Semir Beyaz, Noga Rogel, Christopher Smillie, Karthik Shekhar, Alexandra Schnell, Zuojia Chen, Chuan Wu, Jose Ordovas-Montanes, David Alvarez, Rebecca H. Herbst, Itay Tirosh, Grace Burgin, Danielle Dionne, Michael E. Xifaras, Mei Zhang, Alex K. Shalek, Ulrich H. von Andrian, Daniel B. Graham, Orit Rozenblatt-Rosen, Hai Ning Shi, Vijay Kuchroo, Omer Yilmaz, Aviv Regev, Ramnik J. Xavier
bioRxiv 217133; doi: https://doi.org/10.1101/217133
T helper cells modulate intestinal stem cell renewal and differentiation
Moshe Biton, Adam L. Haber, Semir Beyaz, Noga Rogel, Christopher Smillie, Karthik Shekhar, Alexandra Schnell, Zuojia Chen, Chuan Wu, Jose Ordovas-Montanes, David Alvarez, Rebecca H. Herbst, Itay Tirosh, Grace Burgin, Danielle Dionne, Michael E. Xifaras, Mei Zhang, Alex K. Shalek, Ulrich H. von Andrian, Daniel B. Graham, Orit Rozenblatt-Rosen, Hai Ning Shi, Vijay Kuchroo, Omer Yilmaz, Aviv Regev, Ramnik J. Xavier
bioRxiv 217133; doi: https://doi.org/10.1101/217133
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